补肺平喘汤联合现代医学疗法治疗哮喘-慢阻肺重叠综合征临床研究

Clinical Study on Bufei Pingchuan Tang Combined with Modern Medicine Therapy for Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome

目的:观察补肺平喘汤联合现代医学疗法治疗哮喘-慢阻肺重叠综合征(ACOS)的临床疗效。方法:选取84例ACOS患者,按随机数字表达分为对照组及治疗组各42例。对照组予以沙美特罗替卡松粉吸入剂与噻托溴铵粉雾剂联合吸入,治疗组在对照组治疗基础上加用补肺平喘汤,2组均连用8周。比较2组临床疗效,比较2组治疗前后哮喘症状(ACT)、慢阻肺症状(CAT)评分及肺功能指标[第1秒用力呼气容积(FEV1)、FEV1与用力呼气肺活量(FVC)的比值FEV1/FVC]的变化。结果:治疗组临床疗效总有效率为95.24%,对照组为80.95%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组ACT评分均较治疗前上升,CAT评分均较治疗前下降,差异均有统计学意义(P<0.05);治疗后,治疗组ACT评分高于对照组,CAT评分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组FEV1、FEV1/FVC指标值均较治疗前上升(P<0.05),治疗组上述2项指标值均高于对照组,差异均有统计学意义(P<0.05)。结论:补肺平喘汤联合现代医学疗法治疗ACOS的疗效确切,能改善患者临床症状,改善肺功能。

Objective:To observe the clinical effect of Bufei Pingchuan tang combined with modern medicine therapy for asthma-chronic obstructive pulmonary disease overlap syndrome(ACOS).Methods:A total of 84 cases of ACOS patients were divided into the control group and the treatment group according to their random number table method,with 42 cases in each group.The control group was treated with inhalation with salmeterol/ticasone combined with tiotropium,and the treatment group was additionally treated with Bufei Pingchuan tang based on the treatment of the control group.Both groups were treated for eight weeks.The clinical effects in the two groups were compared.Before and after treatment,the changes in scores of Asthma Control Test(ACT) and COPD Assessment Test(CAT),and lung function indexes including forced expiratory volume in one second(FEV1) and FEV1to forced vital capacity(FEV1/FVC) ratio in the two groups were compared.Results:The total effective rate of clinical effect was 95.24% in the treatment group and 80.95% in the control group,the difference being significant(P<0.05).After treatment,ACT scores in the two groups were increased when compared with those before treatment,and CAT were decreased,differences being significant(P<0.05).After treatment,ACT score in the treatment group was higher than that in the control group,and CAT score was lower,differences being significant(P<0.05).After treatment,the values of FEV1and FEV1/FVC in the two groups were increased when compared with those before treatment(P<0.05),and the two values in the treatment group were higher than those in the control group,differences being significant(P<0.05).Conclusion:Bufei Pingchuan tang combined with modern medicine therapy has a definite curative effect in treating ACOS,and can effectively improve clinical symptoms and lung function.