补肾化瘀方联合西药治疗多囊卵巢综合征不孕症临床研究

Clinical Study on Bushen Huayu Prescription Combined with Western Medicine for Infertility with Polycystic Ovary Syndrome

目的:观察补肾化瘀方联合西药治疗多囊卵巢综合征(PCOS)不孕症的疗效。方法:选取78例PCOS不孕症患者,按随机数字表法分为治疗组40例及对照组38例,对照组给予西药治疗,治疗组在对照组基础上给予补肾化瘀方治疗。比较2组临床疗效,比较2组治疗前后中医证候积分及性激素[黄体生成素(LH)、睾酮(T)、雌二醇(E2)]水平的变化,随访观察3个月后2组排卵率、妊娠率。结果:治疗后,治疗组、对照组临床疗效总有效率分别为90.00%、68.42%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降,治疗组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗后,2组血清T、LH水平均较治疗前下降,血清E2水平均较治疗前上升,差异均有统计学意义(P<0.05);治疗后,治疗组血清T、LH水平均低于对照组,血清E2水平高于对照组,差异均有统计学意义(P<0.05)。疗程结束后,随访观察3个月,治疗组排卵率、妊娠率均高于对照组,差异均有统计学意义(P<0.05)。结论:补肾化瘀方联合西药治疗PCOS不孕症可调节血清性激素水平,减轻患者临床症状,提高疗效,提高排卵率、妊娠率。

Objective:To observe the curative effect of Bushen Huayu prescription combined with western medicine for infertility with polycystic ovary syndrome(PCOS).Methods:A total of 78 cases of PCOS patients were selected and divided into the treatment group and the control group according to the random number table method,with 40 and 38 cases in each group respectively.The control group was treated with western medicine,and the treatment group was additionally treated with Bushen Huayu prescription based on the treatment of the control group.The clinical effects in the two groups were compared;Chinese medicine syndrome scores and the changes in the levels of sex hormones including luteinizing hormone(LH),testosterone(T) and estradiol(E2) before and after treatment in the two groups were compared;ovulation rates and pregnancy rates after three months in the two groups were followed up and observed.Results:After treatment,the total effective rate of clinical effect was 90.00% in the treatment group and 68.42% in the control group,the difference being significant(P<0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the treatment group was lower than that in the control group,differences being significant(P<0.05).After treatment,the levels of T and LH in serum in the two groups were decreased when compared with those before treatment,and serum E2levels were increased,differences being significant(P<0.05).After treatment,the levels of T and LH in serum in the treatment group were lower than those in the control group,and serum E2level was higher,differences being significant(P<0.05).After treatment and during three-month follow-up and observation,the ovulation rate and pregnancy rate in the treatment group were higher than those in the control group,differences being significant(P<0.05).Conclusion:The therapy of Bushen Huayu prescription combined with western medicine for infertility with PCOS can regulate the levels of serum sex hormones,alleviate the clinical symptoms of patients and improve the curative effect,ovulation rate and pregnancy rate.