头孢哌酮钠舒巴坦钠在老年脑梗死合并肺部感染患者中的应用效果

Application effect of Cefoperazone Sodium Sulbactam Sodium in elderly patients with cerebral infarction complicated with pulmonary infection

目的探讨头孢哌酮钠舒巴坦钠在老年脑梗死合并肺部感染患者中的应用效果。方法选取2019年5月至2020年8月徐州矿务集团总医院尘肺科的57例老年脑梗死合并肺部感染患者作为研究对象,采用随机数字表法分为对照组(28例)和观察组(29例)。两组患者均予以常规治疗,对照组在常规治疗的基础上予以头孢他啶治疗,观察组在常规治疗的基础上予以头孢哌酮钠舒巴坦钠治疗。比较两组患者治疗前后的血气指标、免疫功能以及炎症因子水平。结果治疗前,两组患者的氢离子浓度指数(pH)值、氧分压(PaO_(2))、二氧化碳分压(PaCO_(2))水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的pH值、PaO_(2)水平均高于治疗前,且观察组治疗后的pH值、PaO_(2)水平高于对照组,差异有统计学意义(P<0.05);两组患者治疗后的PaCO_(2)水平均低于治疗前,且观察组治疗后的PaCO_(2)水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的血清免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的血清IgA、IgG、IgM水平均高于治疗前,且观察组治疗后的血清IgA、IgG、IgM水平高于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者的血清白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的血清IL-6、IL-8、TNF-α水平均低于治疗前,且观察组治疗后的血清IL-6、IL-8、TNF-α水平低于对照组,差异有统计学意义(P<0.05)。结论头孢哌酮钠舒巴坦钠治疗老年脑梗死合并肺部感染可有效改善患者的血气指标,提高免疫能力,减轻炎症反应。

Objective To investigate the application effect of Cefoperazone Sodium Sulbactam Sodium in elderly patients with cerebral infarction complicated with pulmonary infection.Methods A total of 57 elderly patients with cerebral infarction complicated with pulmonary infection in the Department of Pneumoconiosis of General Hospital of Xuzhou Mining Group from May 2019 to August 2020 were selected as the research objects,according to random number table method,they were divided into the control group(28 cases)and the observation group(29 cases).Both groups were given routine treatment,the control group was given Ceftazidime on the basis of conventional treatment,the observation group was given Cefoperazone Sodium Sulbactam Sodium on the basis of conventional treatment.The levels of blood gas index,immune function and inflammatory factor of the two groups before and after treatment were compared.Results Before treatment,there were no significant differences in the levels of hydrogen ion concentration index(pH),partial pressure of oxygen(PaO_(2)),and partial pressure of carbon dioxide(PaCO_(2))between the two groups(P>0.05).The levels of pH and PaO_(2)in the two groups after treatment were higher than those before treatment,and the levels of pH and PaO_(2)in the observation group after treatment were higher than those in the control group,and the differences were statistically significant(P<0.05).The level of PaCO_(2)in the two groups after treatment was lower than that before treatment,and the level of PaCO_(2)in the observation group after treatment was lower than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in the levels of serum immunoglobulin A(IGA),immunoglobulin G(IgG)and immunoglobulin M(IgM)between the two groups before treatment(P>0.05).After treatment,the levels of serum IgA,IgG,and IgM in the two groups were higher than those before treatment,and the levels of serum IgA,IgG,and IgM in the observation group after treatment were higher than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there were no statistical differences in the levels of serum interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)between the two groups(P>0.05).After treatment,the levels of serum IL-6,IL-8 and TNF-αin the two groups were lower than those before treatment,and the levels of serum IL-6,IL-8 and TNF-αin the observation group after treatment were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion Cefoperazone Sodium Sulbactam Sodium can effectively improve blood gas index,enhance immune ability and reduce inflammatory response in elderly patients with cerebral infarction complicated with pulmonary infection.