早发性脑梗死的影响因素分析

Analysis of the influencing factors of premature cerebral infarction

目的探讨早发性脑梗死的影响因素。方法回顾性分析2019年7月至2021年7月广东省阳江市人民医院收治的106例急性脑梗死患者的临床资料,根据患者发病年龄将其分为早发性脑梗死组49例,非早发性脑梗死组57例。比较两组患者临床资料、家族性高胆固醇血症(FH)患病率与血脂指标的差异,并对早发性脑梗死进行多因素logistics回归分析。结果早发性脑梗死组患者FH患病率高于非早发性脑梗死组,差异有统计学意义(P<0.05)。多因素logistics回归分析显示,卒中史(OR=1.92,95%CI:1.84~3.29)、高血压病史(OR=1.38,95%CI:1.84~1.69)、甘油三酯(TG)(OR=1.83,95%CI:1.36~4.89)、低密度脂蛋白胆固醇(LDL-C)(OR=1.79,95%CI:1.34~4.39)和FH患病(OR=1.98,95%CI:1.70~3.61)是早发性脑梗死的独立危险因素。结论FH、血脂指标是早发性脑梗死发病的独立危险因素,临床上可通过诊断FH,控制血脂水平来预防早发性脑梗死。

Objective To explore the influencing factors of premature cerebral infarction.Methods The clinical data of 106 patients with acute cerebral infarction treated in Yangjiang People′s Hospital from July 2019 to July 2021 were analyzed retrospectively,they were divided into premature cerebral infarction group(n=49)and non premature cerebral infarction group(n=57)according to the age of onset.The clinical data and familial hypercholesterolemia(FH)and blood lipid indexes of the two groups were compared,and multivariate logistic regression analysis was used for premature cerebral infarction.Results The prevalence of FH in premature cerebral infarction group was higher than that in non premature cerebral infarction group,the difference was statistically significant(P<0.05).The multivariate logistic regression analysis showed that history of stroke(OR=1.92,95%CI:1.84-3.29),history of hypertension(OR=1.38,95%CI:1.84-1.69),triglyceride(TG)(OR=1.83,95%CI:1.36-4.89),low density lipoprotein cholesterol(LDL-C)(OR=1.79,95%CI:1.34-4.39)and FH(OR=1.98,95%CI:1.70-3.61)are the independent risk factors of premature cerebral infarction.Conclusion FH and blood lipid indexes are independent risk factors of premature cerebral infarction.Clinically,we can prevent premature cerebral infarction by diagnosing FH and controlling blood lipid level.