IL-36亚家族成员与口腔疾病相关性的研究进展

Research progress on the relationship between IL-36 subfamily members and oral diseases

口腔疾病(oral disease)是给人们带来严重健康和经济负担的全球最流行的疾病之一,其极大地降低了患者的生活质量。白细胞介素-36亚家族(简称“IL-36s”)属于IL-1细胞因子超家族,其与IL-1亚家族氨基酸系列之间的高同源性表明IL-36s同IL-1一样在固有免疫和适应性免疫过程中发挥重要作用。目前已有的研究表明,IL-36s参与脓疱性银屑病、特应性皮炎、类风湿性关节炎和肠道炎症等慢性炎症疾病的病理过程,但关于IL-36s在口腔疾病中的作用仍需深入研究。本文对IL-36s目前在牙周炎、口腔黏膜病、龋病、口腔癌和其在治疗中的研究进展进行综述,为今后更多学者在此领域的研究探讨提供便利。

Oral disease is one of the most popular diseases in the world,which brings serious health and economic burden to people,and greatly reduces the quality of life of patients.The interleukin-36 subfamily(hereinafter referred to as"IL-36s")belongs to the IL-1 cytokine superfamily.Its high homology with the amino acid series of IL-1subfamily indicates that IL-36s,like IL-1,plays an important role in the process of innate and adaptive immunity.At present,existing studies have shown that IL-36s is involved in the pathological process of chronic inflammatory diseases such as pustular psoriasis,atopic dermatitis,rheumatoid arthritis and intestinal inflammation,but the role of IL-36s in oral diseases still needs to be further studied.This article reviews the current research progress of IL-36s in periodontitis,oral mucosal disease,caries,oral cancer and its treatment,and provides convenience for more scholars in the future to study and discuss in this field.