摘要
通过三羟甲基氨基甲烷与BH_(3)·THF反应制得1,3,2-噁唑硼烷络合物,并以其作为氢源,以甲磺酸铜为催化剂,在温和反应条件下(60℃,24 h),实现了芳香醛的一锅法氢转移还原胺化,以45%~80%的产率得到20个二级胺类化合物,其结构经^(1)H NMR确证。
We have developed a copper catalyzed one pot transfer hydrogenation of oxazaborolidine complex and reductive amination of aromatic aldehydes.The reaction was processed under mild condition(60℃,24 h).Copper(II)methane sulfonate was used as a metal catalyst,1,3,2-oxazolborane complex was prepared in situ from tris(hydroxymethyl)aminomethane with BH_(3)·THF as the hydrogen source.Twenty amine derivatives were synthesized in moderate to good yields(45%~80%),its structure was confirmed by ^(1)H NMR.
作者
GIMAH AMY SAMBOLLAH
熊万金
李雷
伍建军
唐鋆磊
周太刚
GIMAH AMY SAMBOLLAH;XIONG Wanjin;LI Lei;WU Jianjun;TANG Junlei;ZHOU Taigang(College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, China;Research Institute of Tianfu New Energy, Chengdu 610299, China)
出处
《合成化学》
CAS
2022年第6期459-465,共7页
Chinese Journal of Synthetic Chemistry
基金
四川省科技计划项目(2021YFH0161)
西南石油大学自然科学“揭榜挂帅”项目(2021JBGS07)
国家自然科学基金青年基金资助项目(21602184)。
关键词
铜催化
一锅法
胺
1
3
2-噁唑硼烷
氢转移
合成
还原胺化
copper catalysis
one-pot method
amines
1,3,2-oxazaborolidine complex
transfer hydrogenation
synthesis
reductive amination
