冠状动脉粥样硬化性心脏病血瘀证表观遗传学研究进展

Research Progress in Epigenetics of Coronary Atherosclerotic Heart Disease with Blood Stasis Syndrome

冠状动脉粥样硬化性心脏病(CHD)是多基因遗传及环境等因素相互作用的复杂性疾病,血瘀证是其常见证型之一。表观遗传学是在基因序列不变基础上,研究基因表达受环境、疾病等影响的可遗传变化的学科,与中医证候本质具有一定相关性,是目前CHD血瘀证研究极具前景的一个领域。本文从表观遗传学在CHD血瘀证治疗、诊断等方面的作用,概述CHD发生的表观遗传学机制,包括DNA甲基化、组蛋白修饰、非编码RNA及染色质重构等,展望其在CHD血瘀证中能作为一种新的诊断指标,为相关基础研究和临床应用提供参考。

Coronary atherosclerotic heart disease(CHD)is a complex disease with the interaction of multiple genetic and environmental factors,and blood stasis syndrome is one of its common syndromes.Epigenetics is a subject that studies the heritable changes of gene expression affected by environment and disease on the basis of unchanged gene sequence.It has a certain correlation with the essence of syndrome and is a promising field in the research of blood stasis syndrome of CHD.Based on epigenetics in CHD treatment and diagnosis of blood stasis syndrome,this article summarized the mechanism of CHD occurrence of epigenetics including DNA methylation,histone modification,non-coding RNA and chromatin remodeling,looking forward that it can be a new diagnosis index in CHD with blood stasis syndrome,in order to provide reference for basic research and clinical application.