一种新型冷冻探针行冷冻活检术的可行性研究

Feasibility of a new cryoprobe for cryobiopsy

目的探究一种新型冷冻探针行冷冻活检术的可行性。方法使用一种新型冷冻探针及两种传统冷冻探针行离体冷冻活检术,测量并比较不同规格冷冻探针获取活检组织的大小。结果大部分情况下,活检组织块的大小与冷冻时间呈正相关;相同的冷冻时间下,冷冻探针的直径与组织块大小呈正相关。有无冷冻转接头对活检组织的质量和直径的影响均无统计学意义。不同冷冻时间下,新型冷冻探针获取的组织量大小与传统规格冷冻探针相近。结论新型冷冻探针的优势是显著的,其较小的直径能够凭借足够的柔性更易到达肺上叶等常规冷冻探针难以到达的病灶处,同时减少出血情况的发生。虽然其单次获取组织量的大小与传统型号相比有所不足,但可通过灵活调节冷冻时间,从而达到和传统规格冷冻探针相似的组织量大小。

Objective To explore the feasibility of a new cryoprobe for cryobiopsy.Methods A new type of cryoprobe and two types of traditional cryoprobe were used for in vitro transbronchial cryobiopsy.The size of biopsy tissues obtained by different specifications of cryoprobes was measured and compared.Results In most cases,the size of biopsy tissues was positively correlated with the freezing time,and the diameter of cryoprobe was positively correlated with the size of tissues over the same freezing time.There was no significant difference in the mass and diameter of biopsy tissues with or without adoptor.At different freezing time,the tissue size by the new cryoprobe was similar to that by the traditional cryoprobes.Conclusion The significant advantages of the new type of cryoprobe are its smaller diameter and flexibility which allow it easily to reach the upper lobe of the lung and other lesions which are difficult by conventional cryoprobes,and at the same time reduce the occurrence of bleeding;although the size of tissues obtained in a single time by the new cryoprobe is not comparable with the traditional types,it can still achieve the similar amount through adjusting freezing time as appropriate.