六君健脾汤联合甲氧氯普胺片治疗阿片类止痛药所致呕吐42例总结

Clinical effect of Liujun Jianpi decoction combined with metoclopramide tablets in treatment of vomiting induced by opioid painkillers:An analysis of 42 cases

目的:观察六君健脾汤联合甲氧氯普胺片治疗阿片类止痛药所致呕吐的临床疗效。方法:将84例服用阿片类止痛药导致呕吐的患者随机分为2组,每组各42例。对照组予以甲氧氯普胺片治疗,治疗组在对照组治疗的基础上加用六君健脾汤治疗,2组均治疗14 d。观察2组患者治疗前后生活质量(KPS)评分、中医证候积分,并比较临床疗效。结果:总有效率治疗组为92.86%(39/42),对照组为80.95%(34/42),2组比较,差异有统计学意义(P<0.05);2组患者治疗后KPS评分及中医证候积分均较治疗前明显下降(P<0.01),且治疗组下降幅度大于对照组,治疗后组间比较,差异有统计学意义(P<0.05)。结论:六君健脾汤联合甲氧氯普胺片治疗可有效缓解阿片类止痛药引起的呕吐,改善患者的生存质量。

Objective:To investigate the clinical effect of Liujun Jianpi decoction combined with metoclopramide tablets in the treatment of vomiting induced by opioid painkillers.Methods:A total of 84 patients with vomiting induced by opioid painkillers were randomly divided into control group and treatment group,with 42 patients in each group.The patients in the control group were given metoclopramide tablets,and those in the treatment group were given Liujun Jianpi decoction in addition to the treatment in the control group;the course of treatment was 14 days for both groups.The two groups were compared in terms of Karnofsky Performance Scale(KPS)score and traditional Chinese medicine(TCM)syndrome score before and after treatment,and clinical outcome was compared between the two groups.Results:There was a significant difference in overall response rate between the treatment group and the control group[92.86%(39/42)vs 80.95%(34/42),P<0.05].After treatment,both groups had significant reductions in KPS score and TCM syndrome score(P<0.01),and the treatment group had significantly greater reductions than the control group;there were significant differences in these scores between the two groups after treatment(P<0.05).Conclusion:Liujun Jianpi decoction combined with metoclopramide tablets can effectively alleviate vomiting induced by opioid painkillers and improve patients’quality of life.