基于数据挖掘探析中医药治疗肝衰竭的用药规律

Medication rule of traditional Chinese medicine treatment for liver failure based on data mining

目的:基于数据挖掘探析中医药治疗肝衰竭的用药规律。方法:在中国知网(CNKI)、万方数据(WANFANG DATA)、维普中文科技期刊数据库(VIP)、中国生物医学文献服务系统(SinoMed)、PubMed等数据库中检索关于中医药治疗肝衰竭的临床文献。检索时间为自建库以来至2020年6月23日。采用SPSS 23.0软件对数据库中的中药、药性、药味及功效进行频数分析。结果:共纳入文献90篇,其中纳入研究的方剂98首,涉及中药151味,频次>20次的中药共12味,依次为茵陈、赤芍、大黄、丹参、栀子、郁金、茯苓、白术、甘草、虎杖、牡丹皮、黄芩。涉及19种中药功效,排前10位的依次为清热药、利水渗湿药、补虚药、活血化瘀药、理气药、泻下药、止血药、消食药、化痰止咳平喘药、温里药。排前3位的药性依次为寒、温、平,药味依次为甘、苦、辛。结论:肝衰竭主要病因为热毒、湿浊、瘀血,治法以清热解毒、利湿化浊、行气活血为主,其用药存在一定的规律性。

Objective: To investigate the medication rule of traditional Chinese medicine(TCM) treatment for liver failure based on data mining.Methods: Databases including CNKI,Wanfang Data, VIP,SinoMed, and PubMed were searched for clinical articles on TCM treatment of liver failure published up to June 23,2020.SPSS 23.0 was used to perform a frequency analysis of TCM drugs, nature, taste, and function.Results: A total of 90 articles were included, and 98 prescriptions were included for analysis.A total of 151 TCM drugs were involved, among which 12 had a frequency of >20 times, i.e.,Artemisia capillaris, Radix Paeoniae Rubra, Rheum officinale, Salvia miltiorrhiza, Fructus Gardeniae, Curcuma aromatica, Poria cocos, Atractylodes macrocephala Koidz, Radix Glycyrrhizae, Polygonum cuspidatum, Cortex Moutan Radicis, and Scutellaria baicalensis.A total of 19 functions were involved, and the top 10 functions were heat-clearing drugs, diuresis-inducing and dampness-draining drugs, deficiency-tonifying drugs, blood-activating and stasis-resolving drugs, Qi-regulating drugs, purgative drugs, hemostatic drugs, digestion-promoting drugs, phlegm-eliminating/cough-relieving/asthma-relieving drugs, and interior-warming drugs.The top 3 drug natures were cold, warm, and neutral, and the top 3 drug tastes were sweet, bitter, and pungent.Conclusion: Heat toxin, damp turbidity, and blood stasis are the main etiologies of liver failure, and the treatment of liver failure mainly focuses on clearing heat and detoxicating, promoting diuresis and eliminating turbid pathogen, and moving Qi and activating blood, which shows a certain degree of regularity.