基于中医传承辅助平台分析舒兰治疗小儿过敏性鼻炎的用药规律

Shu Lan’s medication rule in treatment of pediatric allergic rhinitis based on Traditional Chinese Medicine Inheritance Support System

目的:基于中医传承辅助平台分析舒兰教授治疗小儿过敏性鼻炎(AR)的用药规律。方法:收集2020年12月1日至2021年10月31日在湖南中医药大学第一附属医院国医堂门诊经舒兰教授诊治的小儿AR中药处方,经过筛选,共获得有效处方206首。借助中医传承辅助系统(V2.5),采用关联规则、复杂系统熵聚类分析等方法进行数据挖掘和可视化分析,总结药物的应用频次、药对组合、新方组合。结果:用药频次>60次的药物依次为:甘草、辛夷、白芷、鸡内金、苍耳子、桔梗、薄荷、石菖蒲、路路通、桑叶、黄芩、茯苓、菊花。得出频次>89次的药对共35对,排前6位者分别为:甘草-辛夷、白芷-甘草、鸡内金-甘草、甘草-苍耳子、苍耳子-辛夷、白芷-辛夷。并得出核心组合18个,新处方10首。结论:舒教授临床治疗AR多从风邪论治,重视祛风抗敏,根据所兼夹寒、热之邪的不同,或以辛散温通,或以清宣通利,兼以健脾、化痰、养阴、散结,获效颇佳,为中医药治疗小儿AR拓宽了思路。

Objective:To investigate the medication rule of Professor Shu Lan in the treatment of pediatric allergic rhinitis(AR)based on Traditional Chinese Medicine Inheritance Support System.Methods:Traditional Chinese medicineprescriptions for pediatric AR were collected from the cases diagnosed and treated by Professor Shu Lan at the outpatient service of Guoyitang,The First Affiliated Hospital of Hunan University of Chinese Medicine,from December 1,2020 to October 31,2021,and 206 effective prescriptions were obtained after screening.With the help of Traditional Chinese Medicine Inheritance Support System(V2.5),the methods such as association rule and complex system entropy clustering were used for data mining and visual analysis to summarize the application frequency of drugs,drug combinations,and new prescriptions.Results:The drugs with an application frequency of>60 times were Radix Glycyrrhizae,Flos Magnoliae,Radix Angelicae Dahuricae,Chicken’s Gizzard-membrane,Fructus Xanthii,Platycodon grandiflorus,Mentha haplocalyx,Rhizoma Acori graminei,Liquidambaris Fructus,mulberry leaves,Scutellaria baicalensis,Poria cocos,and Chrysanthemum morifolium.There were 35 drug combinations with a frequency of>89 times,and the top 6 drug combinations were Radix Glycyrrhizae-Flos Magnoliae,Radix Angelicae Dahuricae-Radix Glycyrrhizae,Chicken’s Gizzard-membrane-Radix Glycyrrhizae,Radix Glycyrrhizae-Fructus Xanthii,Fructus Xanthii-Flos Magnoliae,and Radix Angelicae Dahuricae-Flos Magnoliae.A total of 18 core combinations and 10 new prescriptions were obtained.Conclusion:In the clinical treatment of AR,Professor Shu gives treatment from wind pathogen,emphasizes the importance of dispelling pathogenic wind and treatment against allergy,and applies the drugs for pungent dissipating andwarmlydredging or stagnated heat clearing based on the differences in cold or heat pathogen,in combination with the therapies for strengthening the spleen,removing phlegm,nourishing Yin,and resolving static blood,which has achieved a marked clinical effect and provides ideas for the traditional Chinese medicine treatment of pediatric AR.