长链非编码RNA在肾间质纤维化中的研究进展

Research Progress of Long Non-coding RNA in Renal Interstitial Fibrosis

肾间质纤维化在肾脏疾病的进展中起重要作用,是终末期肾病的重要病理特征。目前肾间质纤维化的防治已成为研究难点,通过控制加重肾功能恶化和肾纤维化的危险因素改善患者预后并不能取得满意疗效。长链非编码RNA(lncRNA)在肾缺血、损伤、炎症、纤维化、肾小球疾病、肾移植以及肾癌中的作用已得到业界公认。不同的lncRNA通过不同的靶点对肾间质纤维化具有双重作用(促进与抑制),但具体机制仍需进一步研究验证。未来,深入研究lncRNA在肾间质纤维化中的作用,可以为肾脏疾病的诊疗提供新靶点。

Renal interstitial fibrosis plays an important role in the progression of renal disease and is an important pathological feature of end-stage renal disease.At present,the prevention and treatment of renal interstitial fibrosis has become a research difficulty,since controlling the risk factors of the renal function deterioration and renal fibrosis to improve the prognosis of the patients cannot achieve satisfactory results.The role of long non-coding RNA(lncRNA)in renal ischemia,injury,inflammation,fibrosis,glomerular disease,renal transplantation and renal cell carcinoma has been recognized in the field.Different lncRNAs have dual effects(promotion and inhibition)on renal interstitial fibrosis through different targets,but the specific mechanism remains to be further studied.In the future,in-depth study of the role of lncRNA in renal interstitial fibrosis can provide new targets for the diagnosis and treatment of renal diseases.