特异性氨基酸代谢在前列腺癌中的研究进展

Research Progress of Specific Amino Acid Metabolism in Prostate Cancer

近年代谢组学研究在肿瘤领域深入展开,其中前列腺癌特异性氨基酸代谢的差异性改变已用于前列腺癌的诊断和治疗。某些氨基酸生物合成代谢途径缺乏,会对前列腺癌细胞代谢产生特异影响,但对正常细胞却无影响,因此根据特异性氨基酸代谢的差异性行靶向治疗具有广泛的临床应用潜力。未来深入了解前列腺癌细胞中的氨基酸代谢变化及其相关的分子机制,可以为探究前列腺癌的病因、寻找新的靶向标志物以及制订个性化的治疗策略提供依据。

In recent years,metabolomics research has been deeply developed in the field of tumors,and some differential changes of prostate cancer specific amino acid metabolism have been used in the diagnosis and treatment of prostate cancer.Taking into account the lack of certain amino acid biosynthetic metabolic pathways,these metabolic pathways have a specific effect on the metabolism of prostate cancer cells,but have no effect on normal cells,so the targeted therapy has a wide range of clinical application potential.Understanding the amino acid metabolism changes in prostate cancer cells and the related molecular mechanisms can provide a basis for exploring the etiology,searching for new targeted markers,and developing individualized treatment strategies of prostate cancer.