FTO基因多态性与妊娠期糖尿病关系的meta分析

Association between FTO gene polymorphisms of pregnant women and their gestational diabetes mellitus occurrence:a meta-analysis

目的:探讨脂肪量与肥胖(FTO)相关基因rs9939609和rs8050136位点多态性与妊娠期糖尿病(GDM)的关系。方法:检索Pubmed、EMBASE、万方、web of science和中国知网等数据库中关于FTO基因rs9939609和rs8050136位点多态性与GDM关系研究的文献,并按照纳入和排除标准进行筛选。通过随机或固定效应模型,计算OR值和95%CI评估两者关系。结果:共纳入11篇文献,GDM患者2364例,健康孕妇4425例。FTO(rs9939609)基因3种模型AA比TT(OR=1.53,95%CI 1.22-1.91,Ph=0.164)、AA比TT+AT(OR=1.43,95%CI1.17-1.74,Ph=0.500)和AA+AT比TT(OR=1.22,95%CI 1.04-1.44,Ph=0.054)提示FTO(rs9939609)基因多态性与GDM易感性有关,根据观察组样本量大小和基因分型方法进行亚组分析,FTO(rs9939609)基因多态性在样本量>150、RT-PCR和Taq-Man组均与GDM易感性有关。FTO(rs8050136)基因5种模型均无统计学意义。结论:FTO基因rs9939609位点多态性可能是GDM的易感相关多态位点,而FTO基因rs8050136位点多态性可能与GDM易感性无关。

Objective:To investigate the association between the fat mass and obesity(FTO)related gene polymorphisms in rs9939609 and rs8050136 sites of pregnant women and their gestational diabetes mellitus(GDM)occurrence.Methods:The literatures about the association between the FTO related gene polymorphisms in rs9939609 and rs8050136 sites of the pregnant women and their GDM occurrence were searched from databases,such as Pubmed,EMBASE,and Wanfang,and web of science.The literatures were screened according to inclusion and exclusion criteria.Odds ratio(OR)and 95%CI were used to assess the association between the FTO related gene polymorphisms in rs9939609 and rs8050136 sites of the pregnant women and their GDM occurrence by random or fixed-effect models.Results:A total of 11 literatures were included in this meta-analysis,which were 2364 women with GDM and 4425 healthy pregnant women.In the three models of FTO related gen polymorphisms in rs9939609 site,the OR of AA to TT was 1.53(95%CI:1.22-1.91,Ph=0.164),the OR of AA to TT+AT was 1.43(95%CI 1.17-1.74,Ph=0.500),and the OR of AA+AT to TT was OR=1.22(95%CI 1.04-1.44,Ph=0.054).It was suggested that FTO gene polymorphism in RS9939609 site of the women was associated with their GDM susceptibility.The subgroup analysis was conducted according to the sample size of the studies and the genotyping method of the women in the observation group,which had showed that FTO related gene polymorphism in RS9939609 site were all associated with the GDM susceptibility when the sample size>150 cases,or grouping by RT-PCR and Taq-MAN.5 models of FTO related gene polymorphism in RS8050136 site gene had no statistical significance.Conclusion:FTO gene polymorphisms in rs9939609 site of the pregnant women may be a susceptible polymorphic locus of their GDM occurrence,while FTO gene polymorphisms in rs8050136 site may not be associated with their GDM occurrence.