普瑞巴林治疗带状疱疹后神经痛对患者疼痛和睡眠的影响刍议

The Effect of Pregabalin on Pain and Sleep in Patients with Postherpetic Neuralgia

目的 分析带状疱疹后神经痛使用普瑞巴林治疗对于改善疼痛和睡眠的效果。方法 随机选择医院2018年1月—2020年12月期间接诊的80例带状疱疹后神经痛患者,根据随机数字表法进行分组,每组40例,对照组接受氨酚曲马多片治疗,观察组在对照组基础上接受普瑞巴林治疗,比较两组患者的疗效。结果 观察组治疗总有效率(97.50%)高于对照组,差异有统计学意义(χ^(2)=4.507,P=0.033)。观察组治疗后1周、2周、3周和4周NRS评分(5.65±0.36)分、(4.12±0.23)分、(3.50±0.25)分、(2.56±0.12)分小于对照组,差异有统计学意义(t=7.353、8.438、7.116、21.091,P<0.001)。观察组治疗后1周、2周、3周和4周的PSQI评分(13.63±2.12)分、(9.23±2.52)分、(7.52±3.12)分、(3.58±1.05)分小于对照组,差异有统计学意义(t=7.259、10.038、4.211、8.622, P<0.001)。观察组治疗后1周、2周、3周和4周DLQI评分(10.63±2.05)分、(8.15±1.65)分、(5.15±2.63)分、(3.05±1.00)分小于对照组,差异有统计学意义(t=5.162、7.052、5.621、9.264,P<0.001)。结论 带状疱疹后神经痛患者应用普瑞巴林治疗的效果显著,可以有效改善患者的疼痛评分和睡眠质量,值得在临床中推广使用。

Objective To analyze the effect of pregabalin in the treatment of postherpetic neuralgia on improving pain and sleep.Methods A total of 80 patients with postherpetic neuralgia admitted to the hospital from January 2018 to December 2020 were randomly selected.According to the random number table method,40 cases in each group,the control group received paracetamol and tramadol tablets treatment,and the observation group received pregabalin on the basis of the control group.The curative effects of the two groups of patients were compared.Results The total effective rate(97.50%)of the observation group was higher than that of the control group,the difference was statistically significant(χ^(2)=4.507,P=0.033).The NRS scores of the observation group at 1 week,2 weeks,3 weeks and 4 weeks after treatment were(5.65±0.36)points,(4.12±0.23)points,(3.50±0.25)points and(2.56±0.12)points lower than those in the control group,the difference was statistically significant(t=7.353、8.438、7.116、21.091,P<0.001).The PSQI scores of the observation group at 1 week,2 weeks,3 weeks and 4 weeks after treatment were(13.63±2.12)points,(9.23±2.52)points,(7.52±3.12)points and(3.58±1.05)points lower than those in the control group,the difference was statistically significant(t=7.259、10.038、4.211、8.622,P<0.001).The DLQI scores of the observation group at 1 week,2 weeks,3 weeks and 4 weeks after treatment were(10.63±2.05)points,(8.15±1.65)points,(5.15±2.63)pointsand(3.05±1.00)points lower than those in the control group,the difference was statistically significant(t=5.162、7.052、5.621、9.264,P<0.001).Conclusion The effect of pregabalin in the treatment of patients with postherpetic neuralgia is significant,which can effectively improve the pain score and sleep quality of patients,and it is worthy of promotion and use in clinical practice.