血清PTX3、IL-10、HBP检测在肺结核诊断中的临床意义

Clinical significance of serum PTX3,IL-10,and HBP detection in the diagnosis of pulmonary tuberculosis

目的分析血清正五聚蛋白(PTX3)、白介素-10(IL-10)、肝素结合蛋白(HBP)检测在肺结核诊断中的临床意义。方法选取某院2018年12月—2021年6月收治的122例肺结核患者为结核组,依据肺部有无空洞分为有空洞组和无空洞组;另选取该院同期行健康体检人群113例为对照组,以及潜伏感染者109例为潜伏感染组。对比不同人群、有无肺部空洞者PTX3、IL-10、HBP表达水平;对比治疗后空洞吸收者与未吸收者PTX3、IL-10、HBP表达水平;对比肺结核患者治疗后1、2、3个月PTX3、IL-10、HBP表达水平,分析PTX3、IL-10、HBP对肺结核诊断的价值。结果结核组PTX3、IL-10、HBP表达水平均高于潜伏感染组与对照组,差异均有统计学意义(均P<0.05)。有空洞组PTX3、IL-10、HBP表达水平均高于无空洞组,差异均有统计学意义(均P<0.001)。治疗后空洞吸收组PTX3、IL-10、HBP表达水平均低于空洞未吸收组,差异均有统计学意义(均P<0.001)。治疗后PTX3、IL-10、HBP水平呈逐渐降低趋势,3个月肺结核患者PTX3、IL-10、HBP水平低于治疗后1、2个月,差异均有统计学意义(均P<0.05)。PTX3、IL-10、HBP对肺结核诊断的曲线下面积(AUC)分别为0.756、0.745、0.752,PTX3稍高于IL-10、HBP,但三者间比较差异无统计学意义(P>0.05)。结论PTX3、IL-10、HBP在肺结核患者中均为高表达,有望成为肺结核患者病情评估的参考指标,为临床诊疗提供新思路。

Objective To analyze the clinical significance of serum pentraxin(PTX3),interleukin(IL-10),and heparin-binding protein(HBP)in the diagnosis of pulmonary tuberculosis(PTB).Methods 122 patients with PTB treated in a hospital from December 2018 to June 2021 were selected as the tuberculosis group,they were subdivided into cavity group and non-cavity group according to whether there was a pulmonary cavity;113 patients who underwent physical examination in this hospital during the same period were selected as control group,and 109 patients with latent infection were selected as latent group.The expression levels of PTX3,IL-10,and HBP in different populations and with or without pulmonary cavity were compared;the expression levels of PTX3,IL-10,and HBP were compared between patients with and without cavity absorption after treatment;the expression levels of PTX3,IL-10,and HBP in patients with PTB after 1,2 and 3 months treatment were compared,the value of PTX3,IL-10,and HBP in the diagnosis of PTB were analyzed.Results The expression levels of PTX3,IL-10,and HBP in tuberculosis group were all higher than those in latent infection group and control group,differences were all significant(all P<0.05).The expression levels of PTX3,IL-10,and HBP in cavity group were all higher than those in non-cavity group,differences were all significant(all P<0.001).After treatment,the expression levels of PTX3,IL-10,and HBP in the cavity absorption group were all lower than those in cavity non-absorption group(all P<0.001).Levels of PTX3,IL-10,and HBP decreased gradually after treatment,levels of PTX3,IL-10,and HBP in patients with PTB at 3 months were all lower than those at 1 and 2 months after treatment(all P<0.05).The area under the curve(AUC)of PTX3,IL-10,and HBP for the diagnosis of PTB were 0.756,0.745 and 0.752 respectively,PTX3 was slightly higher than IL-10,and HBP,but there was no significant difference among the three(P>0.05).Conclusion PTX3,IL-10,and HBP are highly expressed in patients with PTB,which is expected to become a reference indicator for the evaluation of disease condition of patients with PTB,and provide new ideas for clinical diagnosis and treatment.