老年缺血性脑卒中颈动脉狭窄患者血清炎症因子水平检测的临床价值

Clinical significance of serum inflammatory factors in elderly patients with carotid artery stenosis after ischemic stroke

目的 探讨老年缺血性脑卒中合并颈动脉狭窄患者血清炎症因子水平检测的临床意义。方法 选取2020年3月-2021年3月长沙市第三医院收治的2068例老年缺血性脑卒中且伴有颈动脉狭窄的患者为观察组,再根据观察组患者颈动脉彩色多普勒超声检查结果分为轻度狭窄组(348例)、中度狭窄组(986例)和重度狭窄组(734例),另选取同期于本院体检合格的志愿者1031名为对照组。测定入选对象超敏C反应蛋白(Hs-CRP)、白介素-6(IL-6)、白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平,比较观察组和对照组Hs-CRP、IL-6、IL-8、TNF-α水平,轻度狭窄组、中度狭窄组和重度狭窄组Hs-CRP、IL-6、IL-8、TNF-α水平,通过Spearman分析颈动脉狭窄程度与Hs-CRP、IL-6、IL-8、TNF-α水平的相关性。结果 观察组Hs-CRP、IL-6、IL-8、TNF-α水平均显著高于对照组(P<0.05)。随着老年缺血性脑卒中患者颈动脉狭窄程度的加深,患者Hs-CRP、IL-6、IL-8、TNF-α水平均呈上升趋势(P<0.05)。经相关性分析,颈动脉狭窄程度与Hs-CRP、IL-6、IL-8、TNF-α水平均呈正相关,差异有统计学意义(P<0.05)。结论 老年缺血性脑卒中且伴有颈动脉狭窄患者血清炎症因子水平处于明显异常状态,且其水平表达与颈动脉狭窄程度具有明显相关性。

Objective To investigate the clinical significance of serum inflammatory factors in elderly patients with ischemic stroke complicated with carotid artery stenosis.Methods 2068elderly patients with ischemic stroke and carotid stenosis from March 2020to March 2021were selected as the observation group.According to the results of carotid color Doppler ultrasonography in the observation group,the patients were divided into mild stenosis group(348cases),moderate stenosis group(986cases)and severe stenosis group(734cases),In addition,1031volunteers who passed the physical examination in our hospital in the same period were included as the control group.High sensitivity C-reactive protein(Hs-CRP),interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)level were measured,The levels of Hs-CRP,IL-6,IL-8,TNF-αin the observation group and the control group were compared,The levels of Hs-CRP,IL-6,IL-8,TNF-αin mild stenosis group,moderate stenosis group and severe stenosis group were compared,Spearman was used to analyze the correlation between the degree of carotid stenosis and the levels of Hs-CRP,IL-6,IL-8and TNF-α.Results The levels of Hs-CRP,IL-6,IL-8and TNF-αin the observation group were significantly higher than those in the control group(P<0.05).With the deepening of carotid stenosis in elderly patients with ischemic stroke,the levels of Hs-CRP,IL-6,IL-8and TNF-αincreased(P<0.05).By correlation analysis,the degree of carotid stenosis was positively correlated with the levels of Hs-CRP,IL-6,IL-8and TNF-α(P<0.05).Conclusion The level of serum inflammatory factors in elderly patients with ischemic stroke and carotid stenosis was significantly abnormal,and its expression was significantly correlated with the degree of carotid stenosis.