非结核分枝杆菌的致病机制研究进展

Research progress on pathogenic mechanism of nontuberculous mycobacterium

非结核分枝杆菌(Nontuberculous mycobacteria,NTM)是除麻风分枝杆菌、结核杆菌复合群以外的分枝杆菌。近年来,NTM的感染人数逐年增多,而且NTM对治疗结核杆菌的药物大部分耐药,导致NTM病防治困难,因此NTM感染致病机制的研究备受关注。本文主要从生物膜的形成、感染宿主细胞和其在HIV合并感染中的致病作用等方面的致病机制做一综述,为该病的临床防治提供依据。

Nontuberculous mycobacteria(NTM) are mycobacteria other than Mycobacterium leprae and Mycobacterium tuberculosis complex.In recent years,the number of NTM infections is increasing year by year,and NTM is resistant to most of the drugs used to treat Mycobacterium tuberculosis,which makes the prevention and treatment of NTM disease difficult.Therefore,the research on the pathogenic mechanism of NTM infection has attracted much attention.In this paper,the pathogenic mechanism of biofilm formation,infection of host cells and its pathogenic role in HIV co-infection is reviewed to provide evidence for the clinical prevention and treatment of the disease.