支原体在肿瘤发生发展中的研究进展

Research progress of mycoplasma in tumor genesis and development

支原体是一类遗传物质简单,且广泛分布自然界中的最小原核微生物,它可在哺乳动物体内持续感染,引起慢性炎症。这种由支原体引起的慢性持续感染被发现与肿瘤的发生发展有着密切的联系。研究表明,支原体可通过多种方式干扰宿主细胞的正常功能,促进肿瘤基因的异常表达、诱导宿主细胞DNA损伤和修复抑制、参与宿主细胞异常甲基化,抑制p53的活性、激活NF-κB活性,促进肿瘤的侵袭和转移,甚至降低抗肿瘤药物疗效等途径参与肿瘤的发生发展。本文主要综述了支原体的感染在肿瘤的发生发展中的作用,为支原体的致瘤机制研究及肿瘤的防治提供新思路。

Mycoplasma is the smallest prokaryotic microorganism with simple genetic material and widely distributed in nature.It can persistently infect mammals and cause chronic inflammation.This chronic infection caused by mycoplasma has been found to be closely related to the occurrence and development of tumors.Studies have shown that mycoplasma can interfere with the normal function of host cells in a variety of ways,induce the high expression of oncogenes,affect the DNA damage and repair of host cells,participate in the abnormal methylation pattern of host cells,inhibit the activity of p53,activate the activity of NF-κB,and promote the invasion and metastasis of tumors.Mycoplasma reduced the efficacy of anti-tumor drugs to participate in the development of tumors.In this paper,the role of mycoplasma infection in the occurrence and development of tumors was reviewed,providing new ideas for the study of mycoplasma tumorigenesis mechanism and tumor prevention and treatment.