卵巢癌液体活检技术研究进展

Research Progress of Liquid Biopsy in Ovarian Cancer

卵巢癌是一种病死率较高的妇科恶性肿瘤,目前其诊断主要依据影像学检查、血清肿瘤标志物以及组织活检。组织活检虽然诊断准确,但具有一定创伤性,目前正在寻找更为方便、快捷以及无创的诊断方法。液体活检是近年来发展起来的一种诊断技术,其在疾病诊断以及预后评估方面有重要价值。目前体液检测在卵巢癌中应用较多的指标有循环肿瘤细胞、循环肿瘤DNA、外泌体及肿瘤相关血小板等,但研究尚处于发展的初级阶段,其广泛用于临床还需要进行更深入和广泛的研究。

Ovarian cancer is a gynecologic malignancy with high mortality,and its diagnosis is mainly based on imaging examination,serum tumor markers and tissue biopsy.Although the tissue biopsy diagnosis is accurate,it is somewhat traumatic,and more convenient,fast and non-invasive diagnostic methods are currently being sought.Liquid biopsy is a diagnostic technique developed in recent years with great value in disease diagnosis as well as prognosis assessment.At present,indicators more often used in ovarian cancer include circulating tumor cells,circulating tumor DNA,exosome and tumor-related platelets,but the research is still in the primary stage of development,and its wide application in clinical still needs more in-depth and extensive research.