摘要
流体剪切应力的机械力学刺激在生物体内转化为生物化学信号,该信号可调节单核-巨噬细胞的表型和功能,如招募单核细胞、影响巨噬细胞吞噬功能和细胞极化方向等,并参与了动脉粥样硬化过程。本文对近年研究进展中流体剪切力作用于单核巨噬细胞的影响和机制作一综述。
The mechanical stimulation of fluid shear stress is transduced into biochemical signals in organisms that regulate the phenotype and functions of monocytes/macrophages. These signals have influences on monocyte recruitment, macrophage phagocytosis and polarization. Then, they participate in process of atherosclerosis. This review covers recent advances in the effects and mechanisms of fluid shear stress on monocytes/macrophages.
作者
张苏慧
张颖倩
惠辉
王威
佟伟
陈韵岱
ZHANG Suhui;ZHANG Yingqian;HUI Hui;WANG Wei;TONG Wei;CHEN Yundai(Medical School of Chinese PLA,Beijing,100853,China;Senior Department of Cardiology,the Sixth Medical Center of PLA General Hospital;Institute of Automation,Chinese Academy of Sciences)
出处
《临床心血管病杂志》
CAS
北大核心
2022年第5期412-417,共6页
Journal of Clinical Cardiology
基金
国家重大科研仪器研制项目(No:81827808)
国家自然科学基金青年科学基金项目(No:81800221)
解放军总医院院内课题军事医学转化项目(No:ZH19027)。
