全国部分省市地区新冠肺炎康复者恢复期血浆采供工作的组织管理

Organization and Management of Collection and Supply for COVID-19 Convalescent Plasma in Some Provinces and Cities in China

目的了解全国采供血机构的新冠康复者恢复期血浆(CCP)组织采集、应急管理等工作做法,探索和进一步完善血站对恢复期血浆采集相关等工作机制。方法自制调查问卷,通过电子邮件方式对自愿参加大陆采供血机构执业比对知识交流(knowledge exchange,KE)的72家全国省市级采供血机构进行问卷调查,调查内容包括组织采集、应急管理及临床输注三方面。结果开展CCP采集工作的机构61家,实际反馈调查问卷42家(17家血液中心,25家中心血站),有效反馈率69%(42/61)。90.5%(38/42)机构的牵头主管单位是省级或当地卫生行政部门。70%以上的机构开展了新冠病毒防疫知识、血浆采集工作和生物安全方面的培训。开展“特殊检测”和“CCP临床输注前免疫学血液检查”的血液中心及中心血站的比例分别为47.1%(8/17)、29.4%(5/17)和16%(4/25)、4%(1/25)。仅35.7%(14/42)的机构收集到CCP临床输注疗效数据。结论卫生行政部门作为CCP工作牵头主管部门的模式已基本形成,但采供血机构在CCP工作中承担的职责未统一明确,规范的CCP输注治疗及应用效果全流程监测信息互通机制尚未建立。

Objective To understand the practices of convalescent plasma of COVID-19(CCP)collection and emergency management in the blood collection and supply institutions in China,and to further improve the mechanism for convalescent plasma collection.Methods Self-made questionnaires,about three aspects including CCP collection,emergency management and clinical infusion,were sent to 72 provincial and municipal blood establishments that voluntarily participated in the knowledge exchange(KE)of mainland in China by email.Results 61 institutions carried out CCP collection work,and 42 actually responded to the questionnaire(17 blood centers and 25 central blood stations),the effective feedback rate was 69%(42/61).90.5%(38/42)of institutions are led by provincial or local health administrative departments.More than 70%of institutions have carried out training on COVID-19 prevention knowledge,plasma collection and biosafety.The proportion of blood centers and central blood stations that carried out the"special testing"for COVID-19 were 47.1%(8/17)and 29.4%(5/17)respectively,as the"pre-infusion immunological test of CCP"were 16%(4/25)and 4%(1/25).Only 35.7%(14/42)of the institutions collected CCP clinical infusion efficacy data.Conclusion The model of the health administrative department as the leading department in charge of the CCP work has basically been formed,but the responsibilities of the blood collection and supply institutions in the work of the CCP have not been unified and clarified,and a standardized information exchange mechanism for the whole-process monitoring of CCP infusion therapy and application effects has not been established.