靶向细胞衰老在血管疾病中的作用及其潜在应用

The role of targeting cell senescence in vascular diseases and its potential application

血管衰老是指血管发生形态、结构改变及功能失常的一系列退行性变化的过程.随着血管衰老、动脉粥样硬化等血管性疾病的发病风险显著增加,血管衰老成为探索衰老相关性血管疾病干预策略的重要方向,改变血管衰老的进程有望延缓心血管疾病发生.细胞衰老是血管衰老的重要基础,以往的研究集中于血管内皮细胞衰老在血管衰老和血管性疾病中的作用,而对于血管平滑肌细胞衰老的认识较少.本文重点讨论了血管细胞中平滑肌细胞的衰老及其在血管性疾病发病中的研究进展,并阐述了血管衰老细胞的清除(senotherapy)在延缓衰老和衰老相关血管性疾病中的作用,以期为促进血管健康和延缓衰老相关血管性疾病提供新策略.

Vascular senescence refers to a series of degenerative changes in vascular morphologies,structures and functions.With vascular aging,the risk of vascular diseases,such as atherosclerosis,increases significantly.Therefore,vascular aging has become an important direction in exploring efficient measures targeting age-related vascular diseases,the delay of which may reduce the incidence of age-related vascular diseases.Cellular senescence is one of the fundamental reasons of vascular aging.Previous studies principally concentrated on the role of vascular endothelial cell senescence in vascular aging and vascular diseases,but the senescence of vascular smooth muscle cells was less understood.This paper reviews the research progress of vascular smooth muscle cell senescence and the roles of cellular senescence in the pathogenesis of aging-related vascular diseases,focusing on serotherapy strategies targeting cellular senescence.We hope to provide new strategies for promoting vascular health and delaying aging-related vascular diseases.