m^(6)A RNA甲基化修饰在炎症性肠病中的研究进展

Research progress of m^(6)A RNA methylation modification in inflammatory bowel disease

炎症性肠病(IBD)是一种慢性肠道炎性疾病, 近年来研究发现m^(6)A甲基化修饰作为哺乳动物细胞中最丰富的mRNA修饰, 与IBD的发生发展有着密切关系。m^(6)A的关键酶(METTL3、METTL4、FTO等)不仅可以调控IBD中炎症、免疫的变化, 同时也能与肠道微环境有着双向反馈调节。本文综述m^(6)A RNA甲基化修饰在IBD中的研究进展, 旨在从表观遗传学层面深入了解IBD的发病机制, 为探索靶向m6A修饰相关蛋白来治疗IBD提供新方向。

Inflammatory bowel disease(IBD)is a chronic inflammatory disorder of the intestine.In recent years,it has been found that m^(6)A methylation,as the most abundant mRNA modification in mammalian cells,is closely related to the occurrence and development of IBD.The key enzymes of m^(6)A(METTL3,METTL4,FTO,etc.)can not only regulate the changes of inflammation and immunity in IBD,but also have bidirectional feedback regulation with intestinal microenvironment.Therefore,this paper focuses on the research progress of m^(6)A RNA methylation modification in IBD in recent years,in order to deeply understand the pathogenesis of IBD from the epigenetic level,and provide a new direction for exploring targeted m^(6)A modification-related proteins to treat IBD in the future.