新生昆明小鼠生长发育过程中背部毛囊发育变化

Developmental changes of dorsal hair follicles during the growth and development of newborn Kunming mice

为了分析昆明小鼠出生后两周内毛发及毛囊的发育特征,以小鼠背部毛发及皮肤为研究对象,探究新生昆明小鼠生长发育过程中背部皮肤组织形态学变化规律。取出生后1~12 d的小鼠毛发及皮肤组织,通过HE染色并使用IPP软件拍照进行图像分析,结果显示出生后第一周,小鼠毛囊形态结构及毛囊数目的变化最为明显,差异显著(P<0.000 1)。因此表明昆明小鼠毛囊的生长发育存在时间差异,其急剧变化期发生在出生后的一周时间内,这个生长发育期可以作为毛囊及皮肤研究的最佳时期。

In order to analyze the development characteristics of hair and hair follicles in Kunming mice after two weeks of born,the hair and skin was taken from the back of mice as the research object, for explore the changes of histomorphological of back skin of newborn Kunming mice when which were growth and development. The hair and skin tissues of mice 1 to 12 days after born were stained with HE and photographed with IPP software for image analysis.The results showed that in the first week after born, the changes of hair follicle morphology and the number of hair follicles were the most obvious, and the difference was significant(P<0.000 1). Therefore, the time difference existed in hair follicle growth and development of Kunming mice, and the period of sharp change occurred within one week after born, which could be used as the best period for hair follicle and skin research.