PVT1及TNF基因多态性与2型糖尿病性肾病病位、病性的相关性研究

The Relationship Between PVT1,TNF Gene Polymorphism and the Location,Disease Nature of Type 2 Diabetic Kidney Disease

目的:探讨浆细胞瘤异位基因(PVT1)rs6918698及肿瘤坏死因子(TNF)rs1800629基因多态性与2型糖尿病性肾病(DKD)病位、病性形成的相关性。方法:收集195例汉族DKD患者,与134例健康人群相对照。以证素辨证体系剖析DKD病位、病性证素的分布特点,并检测基因多态性,探讨两者的相关性。结果:气虚在PVT1rs6918698GC型上分布比例显著升高,与无气虚比较,差异具有统计学意义(P<0.01);痰证在TNFrs1800629GG基因型上分布比例显著升高,与无痰证比较,差异具有统计学意义(P<0.05)。结论:PVT1基因rs6918698多态性与气虚相关,风险基因GC可能是DKD患者多发气虚的遗传学基础之一;TNF基因rs1800629多态性与痰相关,提示风险基因GG可能是DKD患者多发痰证的遗传学基础之一。

Objective:To investigate the relationship between polymorphisms of plasmacytoma heterotopic gene rs6918698(PVT1),tumor necrosis factor rs1800629(TNF)and the location and disease nature of type 2 diabetic nephropathy(DKD).Methods:A total of 195 han patients with DKD were collected and compared with 134 healthy people.The distribution characteristics of DKD syndrome sites and syndrome elements were analyzed by syndrome differentiation,and gene polymorphism was detected.Results:The distribution proportion of Qi deficiency in PVT1RS-6918698GC type was significantly increased,and the difference was statistically significant compared with that without Qi deficiency(P<0.01).The distribution proportion of TNFRS1800629GG genotype in sputum syndrome was significantly increased,and the difference was statistically significant compared with that in no sputum syndrome(P<0.05).Conclusion:PVT1 rs6918698 polymorphism is associated with qi-deficiency,and the risk gene GC may be one of the genetic bases of multiple Qi-deficiency in DKD patients.The rs1800629polymorphism of TNF gene is associated with sputum,suggesting that GG gene may be one of the genetic bases of multiple sputum syndrome in DKD patients.