甲泼尼龙琥珀酸钠联合布地奈德混悬液雾化吸入治疗小儿急性喉炎疗效观察

The Effects of Methylprednisolone Sodium Succinate Combined with Aerosol Inhalation of Budesonide Suspension in the Treatment of Acute Laryngitis in Children

目的探讨甲泼尼龙琥珀酸钠联合布地奈德混悬液雾化吸入治疗小儿急性喉炎的临床疗效。方法收集2019年4月—2021年4月期间盘锦市中心医院收治的80例小儿急性喉炎患儿,随机分为对照组和治疗组各40例。在常规治疗的基础上,给予对照组患儿甲泼尼龙琥珀酸钠静脉滴注治疗;给予治疗组患儿甲泼尼龙琥珀酸钠联合布地奈德混悬液雾化吸入治疗,比较两组患儿的治疗效果及不良反应。结果治疗组总有效率为95%,高于对照组总有效率的75%,差异有统计学意义(P<0.05)。治疗组的各临床症状消失时间以及住院天数均短于对照组,差异均有统计学意义(P<0.05)。治疗后两组高敏C反应蛋白均降低,且治疗组高敏C反应蛋白低于对照组,差异有统计学意义(P<0.05)。结论甲泼尼龙琥珀酸钠联合布地奈德混悬液雾化吸入,治疗小儿急性喉炎的临床效果明显好于单纯使用甲泼尼龙琥珀酸钠,联合用药有效率高且症状改善快,值得临床推广使用。

Objective To observe the clinical effect of methylprednisolone sodium succinate combined with aerosol inhalation of Budesonide suspension in the treatment of acute laryngitis in children.Methods A total of 80 children with acute laryngitis admitted to our hospital from April 2019 to April 2021 were randomly divided into control group and treatment group according to random method,40 cases in each group.On the basis of conventional treatment,the control group was given intravenous infusion of methylprednisolone sodium succinate,and the treatment group was treated with methylprednisolone sodium succinate combined with atomized inhalation of Budesonide suspension.The treatment effect and adverse reactions were compared between the two groups.Results The total effective rate of the treatment group was 95%,which was higher than 75%of the control group(P<0.05).The disappearance time of clinical symptoms and hospitalization days in treatment group were significantly shorter than those in control group(P<0.05).After treatment,the high sensitive C-reactive protein in both groups was decreased,and the high sensitive C-reactive protein in the treatment group was significantly lower than that in the control group(P<0.05).Conclusion The clinical effect of methylprednisolone sodium succinate combined with budesonide suspension atomization inhalation in the treatment of acute laryngitis in children is significantly better than that of methylprednisolone sodium succinate alone.The combination can have high efficiency and rapid symptom improvement,which is worthy of clinical promotion.