注射用两性霉素B胆固醇硫酸酯复合物用药指导原则

Guiding principle for the administration of amphotericin B colloidal dispersion for injection

两性霉素B胆固醇硫酸酯复合物是两性霉素B的含脂制剂,经过结构修饰后显著降低传统两性霉素B的肾毒性,提升临床有效用药剂量,实现更好的治疗效果。抗真菌药物的规范化用药至关重要,本指导原则旨在为两性霉素B胆固醇硫酸酯复合物在临床的安全和有效使用提供建议。

Amphotericin B colloidal dispersion(ABCD)is a novel formulation of amphotericin B with a nearly 1∶1 molar ratio of cholesteryl sulfate to amphotericin B that forms uniform disk-shaped particles 115 nm in diameter and 4 nm thick.Due to the structural modification,ABCD achieved higher drug doses and better therapy efficacy with reduced renal toxicity.Standardized medication for antifungal drugs is very important,therefore the guiding principle aims to provide effective and practical instructions for the use of ABCD.