浅谈实验动物屏障设施的建设及管理体会——以广州中医药大学中药学院实验动物屏障设施为例

Construction and management experience of laboratory animal barrier facilities: Case study of specific pathogen-free barrier facility for laboratory animals in the School of Pharmaceutical Sciences of Guangzhou University of Chinese Medicine

实验动物是教学科研工作中的重要载体和工具,合格的实验动物是科学研究的重要前提。建立标准化、科学化、规范化的实验动物屏障设施可提供SPF级实验动物并为开展实验动物研究提供平台保障。本文将以广州中医药大学中药学院实验动物屏障设施为例,从屏障设施建设情况、规章制度管理、人员培训及管理、灭菌清洁工作、废弃物处理等方面介绍该实验动物屏障设施的运行模式,就管理过程中遇到的常见问题提出相关解决措施,并对未来努力方向提出个人思考,以期为实验动物屏障设施的建设和管理提供参考。

Laboratory animals are important in teaching and scientific research, and qualified laboratory animals are an important prerequisite for scientific research. The establishment of scientific and standardized laboratory animal barrier facilities provides specific pathogen-free laboratory animals and platform support to carry out animal research. This article discusses the specific pathogen-free barrier facility for laboratory animals in the School of Pharmaceutical Sciences of Guangzhou University of Chinese Medicine as an example to introduce the operation mode of the laboratory animal barrier facility from the aspects of construction, management of regulations, personnel training and management, sterilization and cleaning, and waste disposal. We also propose relevant solutions to common problems encountered in the management process. Finally, some opinions on the future direction of laboratory animal barrier facilities will be put forward to provide significant information for the construction and management of laboratory animal barrier facility.