类风湿性关节炎药理实验模型的研究进展

Research and progress of rheumatoid arthritis experimental models

类风湿性关节炎是一种常见的自身免疫病,以慢性滑膜炎症和关节软骨及骨损伤为主要特点,据中医对RA的判定,属于“痹证”范畴。现有药理模型主要包括诱导性模型、自发性基因修饰模型及中医症候模型三大类,本文对类风湿性关节炎药理实验模型进行综述,并对实验模型的理论基础、典型特征、评价方法、主要用途以及与中西医临床病症吻合度进行总结,同时梳理肠道菌群与类风湿关节炎的关系,为后续研究提供参考。

Rheumatoid arthritis(RA) is a common autoimmune disease characterized by chronic synovial inflammation with joint cartilage and bone damage. Under Traditional Chinese Medicine, RA is categorized as a “Bi disease.” Various RA models have been developed, including induced model, spontaneous genetic modification model, and model of Traditional Chinese Medicine syndrome. These models were reviewed and summarized in terms of their theoretical basis, typical characteristics, evaluation method, main usages, and degree of agreement. This paper also deals with the relationship between intestinal flora and RA to provide a reference for follow-up research.