摘要
Coronavirus disease 2019(COVID-19)has become a global pandemic disease.SARS-CoV-2 variants have aroused great concern and are expected to continue spreading.Although many countries have promoted rollout vaccination,the immune barrier has not yet been fully established,indicating that populations remain susceptible to infection.In this review,we summarize the literature on variants of concern and focus on the changes in their transmissibility,pathogenicity,and resistance to the immunity constructed by current vaccines.Furthermore,we analyzed relationships between variants and breakthrough infections,as well as the paradigm of new variants in countries with high vaccination rates.Terminating transmission,continuing to strengthen variant surveillance,and combining nonpharmaceutical intervention measures and vaccines are necessary to control these variants.
基金
This work was supported by the National Natural Science Foundation of China(Nos.82041010,82161138018 and 92169212)
Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response(No.20dz2260100)
Key Discipline Construction Plan from Shanghai Municipal Health Commission(No.GWV-10.1-XK01).
