摘要
血管性认知损害(vascular cognitive impairment,VCI)是仅次于阿尔茨海默病的第2常见痴呆类型。作为中枢神经系统与胃肠道之间的通路,脑肠轴已成为众多疾病发病机制的研究热点之一。肠道菌群失调可能介导或影响动脉粥样硬化、高血压、代谢性疾病和缺血性卒中等血管危险因素,最终加速VCI的发生和发展。文章对肠道菌群与VCI及其主要危险因素的相关文献进行了综述,以期为VCI的预防和治疗提供新思路。
Vascular cognitive impairment(VCI)is the second most common type of dementia after Alzheimer's disease.As the pathway between the central nervous system and gastrointestinal tract,brain-gut axis has become one of the research hotspots in the pathogenesis of many diseases.Intestinal flora imbalance may mediate or affect vascular risk factors such as atherosclerosis,hypertension,metabolic diseases,and ischemic stroke,and finally accelerate the occurrence and development of VCI.This article reviews the literature on intestinal flora and VCI as well as its main risk factors,in order to provide new ideas for the prevention and treatment of VCI.
作者
许莉莉
赵金叶
高雅然
吕佩源
Xu Lili;Zhao Jinye;Gao Yaran;Lyu Peiyuan(Graduate School of Hebei North University,Zhangjiakou 075000,China;Department of Neurology,Hebei General Hospital,Shijiazhuang 050051,China;Graduate School of North China University of Science and Technology,Tangshan 063210,China;Department of Neurology,Hebei Medical University,Shijiazhuang 050017,China)
出处
《国际脑血管病杂志》
2022年第3期210-214,共5页
International Journal of Cerebrovascular Diseases
基金
河北省高端人才资助项目(6833452,83587216)
河北省政府资助临床医学优秀人才培养项目(冀财社:2019-139-5)
河北省引智项目(冀科专函:2020-19-2)。
关键词
胃肠道微生物群
认知功能障碍
卒中
脑缺血
高血压
动脉粥样硬化
糖尿病
2型
危险因素
Gastrointestinal microbiome
Cognitive dysfunction
Stroke
Brain ischemia
Hypertension
Atherosclerosis
Diabetes mellitus,type 2
Risk factors
