阿维A胶囊联合复方甘草酸苷治疗红皮病型银屑病的疗效及安全性Meta分析

Meta-analysis of the Efficacy and Safety of Acitretin Capsule Combined with Compound Glycyrrhizin in the Treatment of Erythrodermic Psoriasis

目的 系统评价阿维A胶囊联合复方甘草酸苷治疗红皮病型银屑病的疗效及安全性。方法计算机检索EMBase、PubMed、中国知网、维普数据库、万方科技等数据库自建库以来关于阿维A胶囊联合复方甘草酸苷治疗红皮病型银屑病的随机对照试验(RCT)。对文献进行筛选后,采用Cochrane制定的Meta分析文献质量评价方法进行质量评价,采用RevMan 5.4软件进行Meta数据分析。结果 共有20篇RCT,涉及1 623例患者纳入研究,其中观察组(阿维A胶囊联合复方甘草酸苷) 800例,对照组(单用阿维A胶囊或复方甘草酸苷)823例。研究结果显示,观察组的治疗效果优于对照组,且发生血脂、肝酶升高和皮肤黏膜干燥等不良反应较对照组明显减少。结论 阿维A胶囊联合复方甘草酸苷治疗红皮病型银屑病的临床疗效优于单纯使用阿维A胶囊或复方甘草酸苷,且安全性更好。

Objective To systematically evaluate the efficacy and safety of Acitretin Capsule(AC) combined with Compound Glycyrrhizin(CG) in the treatment of erythrodermic psoriasis.Methods Randomized control trial(RCT) on treating erythrodermic psoriasis by AC combined CG were retrieved by EMBase,PubMed,CNKI,VIP Database,Wanfang Data,and other database since the establishment of all the database.After screening the literature,Meta-analysis was used for literature quality evaluation set by Cochrane,and RevMan 5.4 Software was used for Meta-analysis.Results A total of 20 RCTs involving 1 623 patients were included in this study,including 800 cases in the observation group(AC+CG) and 823 cases in the control group(AC or CG alone).The results of this study showed that the treatment effect of the observation group was better than that of the control group,and adverse reactions of increased blood lipids and liver enzymes,dry skin and mucous membranes in the observation group significantly decreased more,as compared with the control group.Conclusion The clinical efficacy of AC+CG in the treatment of erythrodermic psoriasis was better than use of AC or CG alone,with better safety.