鼻窦药物支架对嗜酸性粒细胞型鼻窦炎患者的疗效及安全性影响

Efficacy and safety of drug stent for sinus in patients with eosinophilic sinusitis

目的研究鼻窦药物支架对嗜酸性粒细胞型鼻窦炎患者的疗效及安全性影响。方法选择83例嗜酸性粒细胞型鼻窦炎患者,其中男性42例,女性41例;年龄20~60岁,平均年龄36.42岁;体质量43~81 kg,平均体质量55.21 kg。以随机数字表法将所有患者分为药物支架组41例和常规组42例。常规组采用常规治疗,药物支架组采用祥通全降解鼻窦药物支架治疗。分析两组临床疗效、治疗前后主观症状变化情况、满意度情况、术后并发症发生率等方面的差异。结果药物支架组总体有效率97.56%(40/41),明显高于常规组80.95%(34/42)(P<0.05)。术后4周、8周药物支架组主观症状视觉模拟量表(VAS)评分、Lund-Kennedy评分均显著低于常规组[VAS评分:(2.12±0.45)分vs(3.39±0.82)分、(1.56±0.31)分vs(2.23±0.46)分。Lund-Kennedy评分:(2.24±0.34)分us(3.15±0.32)分.(1.60±0.31)分vs(2.08±0.36)分。P=0.000.0.000.0.0000.000];而两组术前、术后12周主观症状VAS评分、Lund-Kennedy评分对比,差异均无统计学意义(P>0.05)。药物支架组总体满意度95.12%(39/41),显著高于常规组[78.57%(33/42)](P<0.05)。药物支架组术后并发症总发生率为2.44%,低于常规组(21.43%)(P<0.05)。结论鼻窦药物支架对嗜酸性粒细胞型鼻窦炎患者的疗效显著,且安全性较佳,可促进患者主观症状的改善,提高满意度,值得临床推广应用。

Objective To study the efficacy and safety of drug stent for nasal sinus in patients with eosinophilic sinusitis.Methods A total of 83 patients with eosinophilic sinusitis were enrolled,which included 42 males and 41 females,aged 20-60 years old with mean age of 36.42 years old;body mass was 43-81 kg with mean body mass of 55.21 kg.All of them were divided into drug stent group(n=41,treated with fully degradable sinus drug stent)and routine group(n=42,treated with routine treatment)by random number table method.The clinical efficacy,changes in subjective symptoms,satisfaction before and after treatment,and incidence of postoperative complications between 2 groups were analyzed.Results The overall effective rate of drug stent group was 97.56%(40/41),which was significantly higher than that of routine group[80.95%(34/42)](P<0.05).The subjective symptom visual analog scale(VAS)score and Lund-Kennedy score 4-week and 8-week post-operation of drug stent group were significantly lower than those of routine group[VAS:(2.12±0.45)scores vs(3.39±0.82)scores,(1.56±0.31)scores vs(2.23±0.46)scores;Lund-Kennedy score:(2.24±0.34)scores vs(3.15±0.32)scores,(1.60±0.31)scores vs(2.08±0.36)scores.P=0.000,0.000,0.000,0.000].There were no significant differences in VAS and Lund-Kennedy score between 2 groups before and 12-week postoperation P>0.05).The overall satisfaction of drug stent group[95.12%(39/41)] was significantly higher than that of routine group[78.57%(33/42)](P<0.05).The total incidence of postoperative complications in drug stent group(2.44%)was lower than that in routine group(21.43%)(P<0.05).Conclusion It is demonstrated that drug stent for sinus showed significant efficacy and safety in patients with eosinophilic sinusitis,which could promote improvement subjective symptoms and satisfaction of patient,and is worthy of clinical application.