乳腺癌组织MAL2和IGF-1R蛋白表达与病理特征及预后的相关性研究

Expression of MAL2 and IGF-1R Protein in Breast Cancer and Its Correlation with Pathological Features and Prognosis

目的探讨乳腺癌组织T细胞分化蛋白2(mal T-cell differentiation protein 2,MAL2)、胰岛素样生长因子1受体(insulin like growth factor 1 receptor,IGF-1R)蛋白表达与病理特征及预后的相关性。方法选取营口市中心医院2015年3月~2016年3月收治的131例乳腺癌患者,采用免疫组织化学法检测乳腺癌患者癌旁正常组织和癌组织MAL2和IGF-1R蛋白表达水平,分析MAL2和IGF-1R蛋白水平与不同病理特点及预后的关系,并采用COX比例风险回归模型分析乳腺癌患者预后影响因素。结果乳腺癌患者癌组织MAL2(77.86%),IGF-1R蛋白(80.15%)阳性率显著高于癌旁正常组织(17.56%,21.37%),差异有统计学意义(χ^(2)=95.482,90.540,均P<0.05);在不同乳腺癌TMN分期以及分化程度上MAL2和IGF-1R蛋白阳性表达率差异均有统计学意义(χ^(2)_(MAL2)=33.545,16.188,χ^(2)_(IGF-1R)=6.533,12.422,均P<0.001)。131例乳腺癌患者随访期间,预后较差患者59例,预后良好患者72例;预后较差组患者MAL2(94.92%),IGF-1R(91.53%)蛋白阳性表达率显著高于预后良好组(36.11%,41.67%),差异均有统计学意义(χ^(2)=18.110,8.727,均P<0.05)。中低分化、III~IV期、MAL2蛋白阳性表达和IGF-1R蛋白阳性表达是患者不良预后的危险因素(P<0.05)。结论MAL2和IGF-1R蛋白在乳腺癌组织中具有较高的表达水平,且与乳腺癌患者TMN分期和分化程度具有明显的相关性,可能是患者不良预后的危险因素之一。

Objective To study the relationship between mal T cell differentiation protein 2(MAL2)and insulin-like growth factor 1 receptor(IGF-1R)and the pathological characteristics and prognosis of breast cancer patients.Methods 131 patients with breast cancer admitted in the Center Hospital of Yingkou City from March 2015 to March 2016 were selected.The expression level of MAL2 and IGF-1R protein were detected by immunohistochemistry in the adjacent normal tissues and cancer tissues of breast cancer patients.The relationship between the level of MAL2 and IGF-1R protein and the pathological characteristics and prognosis of patients with breast cancer were analyzed.COX proportional hazards regression model was used to analyze the prognostic factors of breast cancer patients.Results The positive rates of MAL2(77.86%)and IGF-1R(80.15%)protein in breast cancer tissues were significantly higher than those in adjacent normal tissues(17.56%,21.37%)‚the differences were statistically significant(χ^(2)=95.482,90.540,all P<0.05).The positive rate of MAL2 and IGF-1R protein expression were statistically significant in TMN stage and differentiation degree of different breast cancer(χ^(2)_(MAL2)=33.545,16.188,χ^(2)_(IGF-1R)=6.533,12.422,all P<0.001).During the follow-up period of 131 cases of breast cancer,59 patients with poor prognosis and 72 patients with good prognosis,the MAL2(94.92%)and IGF-1R(91.53%)protein in the poor prognosis group were significantly higher than those in the good prognosis group(36.11%,41.67%),the differences were statistically significant(χ^(2)=18.110,8.727,all P<0.05).Poor differentiation,stage III~IV,positive expression of MAL2 protein and IGF-1R protein were risk factors for poor prognosis(P<0.05).Conclusion MAL2 and IGF-1R protein had high expression level in breast cancer,and they were significantly correlated with TMN stage and differentiation degree of breast cancer patients,At the same time,it may be one of the risk factors for the patient’s poor prognosis.