竞争性内源性RNA在急性髓系白血病中的研究进展

Research Progress of Competitive Endogenous RNA in Acute Myeloid Leukemia

急性髓系白血病(acute myeloid leukemia,AML)是多种因素引起的造血系统恶性疾病,具有很高的复发率及死亡率。非编码RNA在AML的发生发展过程中发挥着重要作用。竞争性内源性RNA(competing endogenous RNA,ceRNA)观点指出,不同的非编码RNA可通过作用于相同的miRNA反应元件(MRE)从而调控基因的表达。目前越来越多的研究表明,非编码RNA作为ceRNA在调控AML的增殖、凋亡、侵袭和耐药等生物学过程中发挥关键作用。该文主要对ceRNA在AML生物学过程中的调控作用,以及治疗和预后中的临床意义作一综述。

Acute myeloid leukemia(AML)is a malignant disease of the hematopoietic system caused by a variety of factors,with a high recurrence rate and mortality rate.Non-coding RNA plays an important role in the occurrence and development of AML.Competing endogenous RNA(ceRNA)point of view points out that different non-coding RNAs can regulate gene expression by acting on the same miRNA response element(MRE).At present,more and more studies have shown that non-coding RNA as ceRNA plays a key role in regulating the biological processes of AML such as proliferation,apoptosis,invasion and drug resistance.This article mainly reviews the regulatory role of non-coding RNA as ceRNA in the biological process of AML,as well as its clinical significance in treatment and prognosis.