抗菌药物联合抑制胃酸分泌药物治疗消化性溃疡的临床疗效

Clinical efficacy of antibacterial drugs combined with drugs that inhibit gastric acid secretion in the treatment of peptic ulcer

目的探讨抗菌药物联合抑制胃酸分泌药物治疗消化性溃疡的临床疗效。方法选取2018年2月至2020年2月本院收治的128例消化性溃疡患者作为研究对象,依据治疗方式不同分为实验组和对照组,每组64例。对照组给予抑酸联合铋剂治疗,实验组在对照组基础上联合抗菌药物治疗,比较两组临床疗效、生存质量指数(GLQI)评分、临床症状积分、幽门螺杆菌清除率、胃肠激素指标[胃泌素(GAS)、胃动素(MTL)、胆囊收缩素(CCK)]、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))水平。结果实验组治疗总有效率为96.88%,明显高于对照组的79.69%,差异有统计学意义(P<0.05)。治疗后,实验组自觉症状、生理功能、社会功能、心理情绪评分均高于对照组,差异有统计学意义(P<0.05)。治疗后,实验组临床症状积分、幽门螺旋杆菌清除率均高于对照组,差异有统计学意义(P<0.05)。治疗后,实验组CD3^(+)、CD4^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异有统计学意义(P<0.05)。治疗后,实验组GAS、CCK均水平低于对照组,MTL水平高于对照组,差异有统计学意义(P<0.05)。结论抗菌药物联合抑制胃酸分泌药物治疗消化性溃疡效果显著,可提高患者生存质量,改善患者临床症状、胃肠激素指标及炎症反应,提高幽门螺杆菌清除率,值得临床推广应用。

Objective To investigate the clinical efficacy of antibacterial drugs combined with drugs that inhibit gastric acid secretion in the treatment of peptic ulcer.Methods A total of 128 patients with peptic ulcer who were treated in our hospital from February 2018 to February 2020 were selected as the research subjects,and they were divided into experimental group and control group according to different treatment methods,with 64 cases in each group.The control group was given acid-suppression combined with bismuth treatment,and the experimental group was given antibiotics drugs on the basis of the control group.The clinical efficacy,gastrointestinal quality of life index(GLQI)score,clinical symptom score,Helicobacter pylori clearance rate,and gastrointestinal hormone indexes(gastrin[GAS],motility[MTL],cholecystokinin[CCK]),T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+))levels were compared between the two groups.Results The total effective rate of treatment in the experimental group was 96.88%,which was significantly higher than 79.69%in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of subjective symptoms,physiological function,social function and psychological emotion in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the clinical symptom score and the clearance rate of Helicobacter pylori in the experimental group were higher than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of CD3^(+) and CD4^(+) in the experimental group were higher than those in the control group,and CD8^(+) in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of GAS and CCK in the experimental group were lower than those in the control group,and the level of MTL were higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Antibacterial drugs combined with drugs that inhibit gastric acid secretion have significant effect on the treatment of peptic ulcer,which can improve the quality of life of patients,improve the clinical symptoms and gastrointestinal hormone indicators and inflammation response of patients,and improve the clearance rate of Helicobacter pylori,which is worthy of clinical application.