无创呼吸机治疗慢性阻塞性肺疾病伴呼吸衰竭的临床效果分析

Analysis of clinical effect of non-invasive ventilator on chronic obstructive pulmonary disease with respiratory failure

目的探究给予慢性阻塞性肺疾病伴呼吸衰竭患者无创呼吸机治疗的临床效果。方法76例慢性阻塞性肺疾病伴呼吸衰竭患者,随机分为实验组与对照组,各38例。对照组进行常规治疗,实验组在对照组基础上进行无创呼吸机治疗。比较两组治疗效果、肺功能指标[第1秒用力呼气容积(FEV1)、每分钟最大通气量(MVV)、最大呼气流量(PEF)]、血气指标[动脉血氧分压(PaO_(2))、动脉血氧饱和度(SaO_(2))、动脉血二氧化碳分压(PaCO_(2))]。结果实验组治疗总有效率为97.37%,高于对照组的84.21%,差异有统计学意义(P<0.05)。治疗后,实验组FEV1为(1.98±0.75)L,MVV为(1.98±0.82)L/s,PEF为(5.24±2.12)L/s,均高于对照组的(1.52±0.72)L、(1.57±0.77)L/s、(4.04±2.15)L/s,差异有统计学意义(P<0.05)。治疗后,实验组PaO_(2)、SaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05)。结论在慢性阻塞性肺疾病伴呼吸衰竭患者治疗中应用无创呼吸机治疗的效果较为理想,可有效改善血气指标,促进肺功能提高,对减轻疾病损害具有重要意义,值得在疾病治疗中应用和推广。

Objective To investigate the clinical effect of non-invasive ventilator on chronic obstructive pulmonary disease with respiratory failure.Methods A total of 76 patients with chronic obstructive pulmonary disease and respiratory failure were randomly divided into experimental group and control group,with 38 cases in each group.The control group received conventional treatment,while the experimental group received non-invasive ventilator therapy based on the control group.Both groups were compared in terms of therapeutic effect,pulmonary function indexes[forced expiratory volume in 1st second(FEV1),maximum ventilation volume(MVV),peak expiratory flow(PEF)],blood gas indexes[arterial partial pressure of oxygen(PaO_(2)),arterial oxygen saturation(SaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2))].Results The total effective rate of the treatment in the experimental group was 97.37%,which was higher than 84.21%in the control group,and the difference was statistically significant(P<0.05).After treatment,the FEV1 of the experimental group was(1.98±0.75)L,the MVV was(1.98±0.82)L/s,and the PEF was(5.24±2.12)L/s,which were all higher than(1.52±0.72)L,(1.57±0.77)L/s,and(4.04±2.15)L/s of the control group,and the difference was statistically significant(P<0.05).After treatment,the PaO_(2) and SaO_(2) in the experimental group were higher than those in the control group,and PaCO_(2) was lower than that in the control group.All the differences were statistically significant(P<0.05).Conclusion Non-invasive ventilator is effective in the treatment of chronic obstructive pulmonary disease with respiratory failure,and it can effectively improve blood gas indicators and lung function,which is of great significance for reducing disease damage.It is worth applying and popularizing in disease treatment.