拉贝洛尔联合硫酸镁治疗妊娠高血压的临床疗效观察

Observation on the clinical efficacy of labelolol combined with magnesium sulphate in the treatment of pregnancy induced hypertension

目的探讨拉贝洛尔联合硫酸镁治疗妊娠高血压的临床疗效。方法110例妊娠高血压患者,随机分为观察组与对照组,各55例。对照组给予硫酸镁治疗,观察组给予拉贝洛尔联合硫酸镁治疗。对比两组治疗前后血压变化情况,新生儿出生后1、5 min Apgar评分,产妇产后出血、早产、新生儿窒息及新生儿宫内窘迫发生情况。结果治疗后,两组收缩压、舒张压均低于本组治疗前,且观察组收缩压、舒张压分别为(133.91±3.02)、(71.01±3.45)mm Hg(1 mm Hg=0.133 kPa),均低于对照组的(147.42±3.56)、(90.01±4.42)mm Hg,差异均有统计学意义(P<0.05)。出生后1、5 min,观察组Apgar评分分别为(7.89±0.87)、(9.34±0.77)分,均明显高于对照组的(6.12±0.96)、(7.99±0.88)分,差异均有统计学意义(P<0.05)。观察组产妇产后出血、早产、新生儿窒息及新生儿宫内窘迫发生率分别为1.8%、1.8%、3.6%、3.6%,均低于对照组的12.7%、12.7%、14.5%、14.5%,差异均有统计学意义(P<0.05)。结论拉贝洛尔联合硫酸镁治疗妊娠高血压疗效确切,不良事件少,值得临床广泛应用。

Objective To discuss the clinical efficacy of labelolol combined with magnesium sulphate in the treatment of pregnancy induced hypertension.Methods A total of 110 patients with pregnancy induced hypertension were randomly divided into observation group and control group,with 55 cases in each group.The control group was treated with magnesium sulfate,and the observation group was treated with labetalol combined with magnesium sulfate.The changes of blood pressure before and after treatment,the neonatal Apgar score at 1 and 5 min after delivery,and the occurrence of postpartum hemorrhage,premature birth,neonatal asphyxia and fetal intrauterine distress were compared between the two groups.Results After treatment,the systolic blood pressure and diastolic blood pressure in the two groups were lower than those before treatment in this group;the systolic blood pressure and diastolic blood pressure in the observation group were(133.91±3.02)and(71.01±3.45)mm Hg(1 mm Hg=0.133 kPa),which were all lower than(147.42±3.56)and(90.01±4.42)mm Hg in the control group;all the differences were statistically significant(P<0.05).At 1 and 5 min after delivery,the neonatal Apgar scores of the observation group were(7.89±0.87)and(9.34±0.77)points,which were significantly higher than(6.12±0.96)and(7.99±0.88)points of the control group,and the differences were statistically significant(P<0.05).The incidence rates of postpartum hemorrhage,premature birth,neonatal asphyxia and fetal intrauterine distress in the observation group were 1.8%,1.8%,3.6%,and 3.6%,which were lower than 12.7%,12.7%,14.5%,and 14.5%in the control group,and the difference was statistically significant(P<0.05).Conclusion Labelolol is effective in the treatment of pregnancy induced hypertension with less adverse events,and is worthy of clinical wide application.