血脂与子宫内膜癌

Blood lipids and endometrial cancer

近年来,随着我国生活水平的提升及饮食结构的改变,高血脂的发病率逐年上升,大量研究证实血脂水平与众多肿瘤的发生发展密切相关。子宫内膜癌(endometrial carcinoma,EC)是女性常见的生殖道恶性肿瘤之一,其与血脂的关系也愈加受到关注。血脂可通过PI3K/AKT通路、雌激素、ROS产生等途径促进EC的发生发展,他汀类药物对EC具有一定的抑制作用,但存在不少争议。本文就血脂与EC发生发展、预后的关系以及降脂类药物在EC中的应用研究做一综述,以期为后续的基础和临床研究提供参考。

In recent years,with the improvement of living standards and dietary changes,hyperlipidemia has increased year by year in China.A large number of studies have demonstrated that blood lipid levels are closely associated with the occurrence and development of various tumors.Endometrial cancer(EC)is one of the most common malignancies of the female genital tract,and its relationship with blood lipids has also attracted more and more attention.Blood lipids may promote the occurrence and development of endometrial cancer through PI3K/AKT pathway,estrogen,and ROS production.Statins also have a certain inhibitory effect on endometrial cancer,but there are still controversies.In this article,we summarize recent studies on the relationship between hypothyroidism and endometrial cancer and the application of lipid-lowering drugs in endometrial cancer in order to provide references for basic research as well as for clinical treatment.