模糊情景下酒精使用障碍患者风险决策功能的探究

A study on risky decision-making function of patients with alcohol use disorder under uncertain situation

目的:探究模糊情景下酒精使用障碍(AUD)患者的风险决策功能的损害情况及影响因素。方法:选取2021年1月至4月在安徽省精神卫生中心住院治疗的男性AUD患者30例(AUD组)及30名同期健康男性作为对照组,使用气球模拟风险任务(BART)对两组被试进行模糊情景下的风险决策功能探究,使用线性回归分析AUD组风险决策功能的影响因素。结果:AUD组吸烟者尼古丁依赖检验量表(FTND)与密西根酒精筛查量表(MAST)评分高于对照组(P均<0.01)。AUD组BART中最后获得金钱总额与赢钱次数更少,所有气球平均打气次数与爆炸次数更多(P<0.05或P<0.01)。线性回归分析结果显示开始饮酒年龄、宾夕法尼亚渴求量表(PACS)评分、贝克焦虑自评量表(BAI)评分、贝克抑郁自评量表(BDI)评分、BART中爆炸气球平均打气次数、所有气球平均打气次数和爆炸次数可能是风险决策功能损害的影响因素。结论:AUD患者在模糊情景下风险决策功能存在损害,这种损害与开始饮酒年龄、PACS、BAI与BDI评分、BART中爆炸气球平均打气次数、所有气球平均打气次数和爆炸次数等因素有关。

Objective:To explore the impairment and the risk factors of risk decision-making function in patients with alcohol use disorder(AUD)under uncertain situation.Method:Thirty male AUD patients who were hospitalized in Anhui Mental Health Center from January 2021 to April 2021(AUD group)and 30 healthy male subjects(control group)in the same period were selected as the research objects.The balloon analogue risk task(BART)was used to explore their risk decision-making function under uncertain situation,and the risk factors of risky decision-making in the AUD group were analyzed by linear regression.Results:The scores of Fagerstrom Test for Nicotine Dependence(FTND)and Michigan Alcoholism Screening Test(MAST)in the AUD group were higher than those in the control group(both P<0.01).Compared with the control group,the total amount of money and winning times of all balloons of BART were less,and the average pumping times and explosion times were more in the AUD group(P<0.05 or P<0.01).Linear regression analysis showed that the age of starting drinking,the scores of Pennsylvania Alcohol Craving Scale(PACS),Beck Anxiety Inventory(BAI)and Beck Depression Inventory(BDI),the average pumping times of exploding balloons,the average pumping times and the number of explosions of BART were the risk factors of risky decision-making function impairment in the AUD group.Conclusion:The risk decision-making function of AUD patients is impaired under uncertain situation,which is related to the age of starting drinking,the scores of PACS,BAI and BDI,the average pumping times of exploding balloons,the average pumping times and the number of explosions of BART.