溃疡性结肠炎患者FIB、DD及PLT水平与疾病进程的关系研究

The Relationship Study of the Levels of FIB,DD and PLT in Ulcerative Colitis Patients,with Their Condition’s Progression

目的:探讨溃疡性结肠炎(UC)患者纤维蛋白原(FIB)、D-二聚体(DD)及血小板(PLT)水平与疾病进程的关系。方法:选取2020年8月至2021年9月就诊本院的UC患者88例为研究对象,另选取同期体检的健康患者44例纳入健康参考组,依照疾病分期不同,将88例患者随机分为缓解期组和活动期组,每组44例。比较3组FIB、DD及PLT水平,并分析不同分期与疾病进程的关系。结果:健康参考组、缓解期组、活动期组FIB、DD及PLT水平比较差异有统计学意义(P<0.05);轻度、中度、重度UC活动期患者FIB、DD及PLT水平比较差异有统计学意义(P<0.05)。结论:UC患者FIB、DD及PLT水平与临床分期、病情严重程度呈正相关,可作为判断疾病病情的指标。

Objective To explore the relationship of ulcerative colitis(UC)patients’levels of FIB,DD,and PLT,with their condition’s progression.Methods Enrolled 88 UC patients treated in author’s hospital(2020-08-2021-09)into this study,at the same time 44 physical examinees as health controls;according to disease’s staging,the 88 UC patients were divided into group A(at remission stage)and group B(at active stage),44 cases for each;compared the levels of FIB,DD,and PLT between above three groups,afterwards,analysed the relationship of different stages with disease’s progression.Results There was statistical difference in the levels of FIB,DD,and PLT between health controls,group A and group B(P<0.05);Also,there was statistical difference in the levels of FIB,DD and PLT between UC patients at mild,mid-and severe degree(P<0.05).Conclusion In UC patients their levels of FIB,DD,and PLT are related to clinical stages,condition’s severity proportionally,therefore,which could be as the indexes for judging disease condition.