细胞自噬与血脑屏障的关系研究进展

Research progress in the relationship of autophagy and blood brain barrier

自噬对细胞具有一定的保护作用,但过度自噬则会导致细胞程序性死亡,称为Ⅱ型程序性细胞死亡。血脑屏障(BBB)在大脑与外周循环之间起保护作用,有助于分子和离子的流入和流出,以维持中枢神经系统的稳态。大量研究表明,细胞自噬在BBB功能中发挥着重要作用,一方面可对BBB的完整性起到损伤或保护作用,另一方面可影响药物、病原体等物质穿越BBB。因此,通过靶向自噬机制中的特定调节分子来调节自噬水平可能影响BBB的功能,进而影响中枢神经系统疾病的发生和发展。本文对细胞自噬与BBB之间关系的研究进展进行综述,以期为预防和治疗BBB损伤相关的疾病提供新思路。

Autophagy has a certain degree of protective effect on cells,but excessive autophagy can lead to programmed cell death,which is calledⅡprogrammed cell death.The blood brain barrier(BBB)plays a protective role between the brain and the peripheral circulation,which helps the inflow and outflow of molecules and ions to maintain the steady state of the central nervous system.A large number of studies have shown that autophagy plays an important role in BBB dysfunction,on the one hand,autophagy can damage or protect the integrity of BBB,and on the other hand,autophagy can also affect the passage of drugs,pathogens and other substances through BBB.Therefore,regulating autophagy level by targeting specific regulatory molecules in autophagy mechanism may affect the function of BBB,and then affect the occurrence and development of central nervous system diseases.The recent advances in the relationship between autophagy and BBB have been reviewed in present paper for hoping to provide new ideas for the prevention and treatment of diseases related to BBB injury.