变应性鼻炎患者血清IL-4、IL-34、IL-10表达水平及意义

The Expression Levels and Significance of Serum IL-4,IL-34 and IL-10 in Patients with Allergic Rhinitis

目的探讨变应性鼻炎患者血清IL-4、IL-34、IL-10表达水平及意义。方法选取2020年4月至2021年4月在本院确诊的60例变应性鼻炎患者作为AR组,60例非变应性鼻炎作为NAR组,并选取同期的60例健康人群作为对照组。采取三组患者的外周静脉血检测血清白细胞介素-4(IL-4)、白细胞介素-34(IL-34)、白细胞介素-10(IL-10)的表达水平,进行对比分析。结果AR组与NAR组的血清IL-4、IL-34均高于对照组,IL-10均低于对照组(P<0.05);AR组的血清IL-4、IL-34高于NAR组,IL-10低于NAR组(P<0.05);Roc分析血清IL-4、IL-34和IL-10对AR患者具有诊断价值(P<0.05)AR患者血清IL-4与血清IL-34呈正相关(r=0.344,P<0.001),血清IL-10与血清IL-34呈负相关(r=-0.234,P=0.022)。结论血清IL-4、IL-34以及IL-10水平异常升高与AR的发生有关。

Objective To explore the expression levels and significance of interleukin-4(IL-4),interleukin-34(IL-34)and interleukin-10(IL-10)in patients with allergic rhinitis(AR).Methods Sixty patients confirmed with AR in the hospital were enrolled as AR group between April 2020 and April 2021,60 patients with non-AR were enrolled as NAR group,and 60 healthy controls were enrolled as control group.The peripheral venous blood in the three groups was collected to detect the expression levels of serum IL-4,IL-34 and IL-10 for comparative analysis.Results The levels of serum IL-4 and IL-34 in AR group and NAR group were higher than those in control group,while IL-10 was lower than that in control group(P<0.05).The levels of serum IL-4 and IL-34 in AR group were higher than those in NAR group,while IL-10 was lower than that in NAR group(P<0.05).ROC analysis showed that serum IL-4,IL-34 and IL-10 were of diagnostic value for AR patients(P<0.05).IL-4 was positively correlated with IL-34(r=0.344,P<0.001),while serum IL-10 was negatively correlated with serum IL-34(r=-0.234,P=0.022).Conclusion The abnormal increase of serum IL-4,IL-34 and IL-10 is related to the occurrence of AR.