液体活检在新生儿脑损伤诊断及预后判断中的应用和展望

Application and prospect of liquid biopsy in diagnosis and prognostic evaluation of neonatal brain injury

液体活检(LB)是一种利用人体体液获取疾病诊治相关信息的技术,已在多个领域,尤其是肿瘤诊治领域广泛开展,并取得突破性进展。LB在新生儿脑损伤,如颅内出血、新生儿缺氧缺血性脑损伤(HIBD)及早产儿脑白质损伤等诊断中的应用已有开展。笔者拟就LB在新生儿脑损伤诊断及预后判断中的优势、应用现状等最新研究进展进行阐述,旨在为临床对新生儿脑损伤的诊断及预后判断提供参考。

Liquid biopsies(LB),a technique using human body fluids to obtain disease information,has been widely carried out in multiple fields and made breakthrough progress,especially in tumor diagnosis and treatment.The application of LB has been developed in the diagnosis of neonatal brain injury,such as intracranial hemorrhage,neonatal hypoxic-ischemic brain damage(HIBD),and brain white matter injury in preterm infants.We intend to describe the latest research progresses of advantages and current application statuses of LB in diagnosis and prognosis evaluation of neonatal brain injury,in order to provide reference for clinical diagnosis and prognosis evaluation of neonatal brain injury.