摘要
人子宫内膜基质细胞蜕膜化(hESCD),是人类胚胎植入和维持妊娠的关键环节。hESCD主要是指排卵后,子宫内膜在孕酮与孕酮受体(PGR)作用下,发生一系列生物学、形态学改变及细胞外基质重建。但是,对于孕酮-PGR信号通路在hESCD过程中的具体分子作用机制,迄今尚未阐明。笔者拟就PGR结构及其亚型,hESCD过程中孕酮-PGR信号通路的生理作用、网络调控,以及PGR水平及其功能异常与hESCD异常疾病关系4个方面的最新研究进展进行阐述。
Human endometrial stroma cell decidualization(hESCD)is a key link in embryo implantation and pregnancy maintenance.hESCD mainly means that endometrium undergoes a series of biological and morphological changes and extracellular matrix reconstruction by effects of progesterone and progesterone receptor(PGR)after ovulation.However,up to now,the specific molecular mechanism of progesterone-PGR signal pathway in hESCD has not been fully elucidated.This paper focuses on recent research status of the structure and subtypes of PGR,physiological function and regulation network of progesterone-PGR signal pathway,and relationship between abnormal PGR and abnormal diseases of hESCD.
作者
黄品秀
曾定元
Huang Pinxiu;Zeng Dingyuan(Reproductive Medicine Center,Liuzhou Maternity and Child Healthcare Hospital,Liuzhou 545001,Guangxi Zhuang Autonomous Region,China)
出处
《中华妇幼临床医学杂志（电子版）》
CAS
2022年第2期245-248,共4页
Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)
基金
国家自然科学基金项目(82001553、82160296)
广西壮族自治区自然科学基金项目(2019JJB140179)
广西壮族自治区重点研发计划(桂科AB18126056)
柳州科技重点研发计划(2018BJ10301)
柳州市科技计划项目(2018DB20501)。
关键词
受体
孕酮
孕酮抵抗
子宫内膜异位症
子宫内膜蜕膜化
反复种植失败
胚胎植入
女(雌)性
Receptors,progesterone
Progesterone resistance
Endometriosis
Decidualization of endometrium
Repeated implantation failure
Embryo implantation
Female
