SOD、DDR1、HIF⁃1α表达与舌鳞状细胞癌病理特征和预后的关系

Relationship between the expression of SOD,DDR1,HIF⁃1αand pathological characteristics,prognosis of tongue squamous cell carcinoma

目的研究超氧化物歧化酶(SOD)、盘状结构域受体1(DDR1)、沉默缺氧诱导因子⁃1α(HIF⁃1α)表达与舌鳞状细胞癌病理特征、预后的关系。方法选取2017年1月至2018年5月河北北方学院附属第一医院收治的118例舌鳞状细胞癌患者为研究组,另选取门诊口腔良性疾病者88例为对照组。比较两组SOD、DDR1、HIF⁃1α表达情况;分析舌鳞状细胞癌SOD、DDR1、HIF⁃1α表达与病理特征的关系及影响患者预后的危险因素。结果研究组SOD、DDR1、HIF⁃1α阳性率高于照组,差异有统计学意义(P<0.05)。SOD、DDR1、HIF⁃1α阳性患者的组织分化程度、瘤体直径、淋巴结转移、TNM分期、浸润深度均高于阴性患者,差异具有统计学意义(P<0.05)。随访结束,患者存活71例。死亡组SOD、DDR1、HIF⁃1α阳性率较生存组高,差异有统计学意义(P<0.05)。组织分化程度、淋巴结转移、TNM分期、浸润深度、SOD、DDR1、HIF⁃1α高表达为影响舌鳞状细胞癌患者预后的危险因素(P<0.05)。结论SOD、DDR1、HIF⁃1α在舌鳞状细胞癌中呈现高表达,检测三者可有效预测患者预后。

Objective To study the relationship between the expression of Superoxide Dismutase(SOD),Disc domain receptor 1(DDR1),Silence hypoxia inducible factor⁃1α(HIF⁃1α)and the pathological characteristics,prognosis of tongue squamous cell carcinoma.Methods 118 patients with tongue squamous cell carcinoma admitted to the First Affiliated Hospital of Hebei North University from January 2017 to May 2018 were selected as the study group,and another 88 patients with benign oral diseases in outpatient clinics were selected as the control group.The expressions of SOD,DDR1 and HIF⁃1αwere compared between the two groups.The relationship between the expressions of SOD,DDR1,and HIF⁃1αin tongue squamous cell carcinoma and the pathological characteristics and the risk factors affecting the prognosis of the patients were analyzed.Results The positive rates of SOD,DDR1,HIF⁃1αin the study group were higher than those in the control group,and the difference was statistically significant(P<0.05).The degree of tissue differentiation,tumor diameter,lymph node metastasis,TNM stage,and depth of invasion of SOD,DDR1,HIF⁃1αinpositive patients were higher than those in negative patients,and the difference was statistically significant(P<0.05).After theend of follow⁃up,71 parents survived.The positive rates of SOD,DDR1,HIF⁃1αin the death group were higher than those in the survival group,and the difference was statistically significant(P<0.05).The degree of tissue differentiation,lymph node metastasis,TNM staging,depth of invasion,and high expression of SOD,DDR1,and HIF⁃1αwere related risk factors affecting the prognosis of patients with tongue squamous cell carcinoma(P<0.05).Conclusion SOD,DDR1 and HIF⁃1αare highly expressed in tongue squamous cell carcinoma,and the detection of three can effectively predict the prognosis of patients.