PD⁃1、PD⁃L1与炎症标志物在胃癌患者中的相关性

Correlation of PD⁃1/PD⁃L1 and inflammatory markers in gastric cancer patients

目的探讨程序性细胞死亡因子1(PD⁃1)、程序性细胞死亡因子配体1(PD⁃L1)与炎症标志物在胃癌患者中表达情况、相关性及临床意义。方法选取中国人民解放军联勤保障部队第九〇一医院肿瘤一科2020年10月至2021年12月收治的92例胃癌患者作为观察组,另选取同期46例胃部良性病变患者作为对照组。比较两组血清PD⁃1、PD⁃L1、炎症标志物C反应蛋白(CRP)、肿瘤坏死因子⁃α(TNF⁃α)表达水平,分析PD⁃1、PD⁃L1与炎症标志物在胃癌中的表达情况、相关性及联合检测的价值。结果观察组血清PD⁃1、PD⁃L1、CRP、TNF⁃α水平高于对照组,差异有统计学意义(t=6.030,5.389,12.142,21.957,P<0.05)。观察组血清PD⁃1、PD⁃L1与CRP、TNF⁃α呈正相关(P<0.05)。血清PD⁃1与胃癌临床病理特征无明显相关性(P<0.05)。血清PD⁃L1、CRP、TNF⁃α与胃癌临床分期、浸润程度呈正相关,与胃癌分化程度呈负相关(P<0.05)。结论胃癌患者血清PD⁃1、PD⁃L1与炎症标志物关系密切,PD⁃L1、炎症标志物对临床分期、浸润程度、分化程度有重要影响,能为临床诊治提供参考依据。

Objective To investigate the correlation and significance of programmed cell death 1(PD⁃1)/programmed cell death ligand 1(PD⁃L1)and inflammatory markers in gastric cancer patients.Methods A total of 92 gastric cancer patients admitted to the Department of Oncology,No.901 Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from October 2020 to December 2021 were selected as the observation group,and 46 patients with benign gastric lesions during the same period were selected as the control group.Serum PD⁃1,PD⁃L1 expression levels,inflammatory markers[C⁃reactive protein(CRP),tumor necrosis factor⁃α(TNF⁃α)]levels were compared between the two groups,and PD⁃1,PD⁃L1 and inflammatory markers were analyzed.Correlation and joint detection value were evaluated.Results The serum levels of PD⁃1,PD⁃L1,CRP and TNF⁃αin the observation group were higher than those in the control group,the difference was statistically significant(t=6.030,5.389,12.142,21.957,P<0.05).Serum PD⁃1,PD⁃L1 in the observation group was positively correlated with CRP and TNF⁃α(P<0.05).There was no significant correlation between serum PD⁃1 and clinicopathological characteristics of gastric cancer.Serum PD⁃L1,CRP,and TNF⁃αwere positively correlated with the clinical stage and infiltration degree of gastric cancer,and negatively correlated with the degree of gastric cancer differentiation.Conclusion Serum PD⁃1 and PD⁃L1 in gastric cancer patients are closely related to inflammatory markers.PD⁃L1 and inflammatory markers have an important influence on clinical stage,degree of infiltration and degree of differentiation,which can provide a reference for clinical diagnosis and treatment.