ERK信号通路介导银屑病角质形成细胞过度增殖的调控机制

Regulatory Mechanism of ERK Signaling Pathway-Mediated Keratinocyte Hyperproliferation in Psoriasis

银屑病是常见的慢性、复发性、炎症性皮肤病,角质形成细胞(keratinocyte,KC)增殖分化失调作为其发病原因之一,具体机制尚未明确。细胞外信号调节激酶(extracellular signal regulated kinase,ERK)信号通路在其中发挥着重要作用,微小RNA(microRNA,miRNA)、长链非编码RNA(lncRNA)、细胞因子等作为ERK信号通路的上游分子参与调控银屑病表皮角质形成细胞的增殖与分化过程。文章旨在对这一通路在银屑病角质形成细胞过度增殖中的作用机制做一综述。

Psoriasis is a common chronic and recurrent inflammatory skin disease.The disorder of keratinocyte(KC)proliferation and differentiation is one of its pathogeneses,but the underlying molecular mechanisms are still largely unknown.The extracellular signal regulated kinase(ERK)signaling pathway is reported to play an important role in KC proliferation and differentiation.MicroRNA(miRNA),long non-coding RNA(lncRNA),cytokines and other upstream molecules of ERK signaling pathway are also involved in the process.The purpose of this article is to review the mechanism of ERK signaling pathway in hyperproliferation of KCs in psoriasis.