卵泡期预处理使用生长激素对高龄卵巢储备功能减退患者超促排卵治疗的影响

Effect of follicular phase pretreatment with growth hormone for advanced diminished ovarian reserve patients following the controlled ovarian hyperstimulation

目的探讨卵泡期预处理使用生长激素对高龄卵巢储备功能减退(DOR)患者超促排卵治疗的影响。方法选取2019年1月至2020年10月均于该院就诊的48例DOR患者作为研究对象。采用随机数字表法分组,24例常规组患者干预方案为超促排卵治疗,24例研究组患者干预方案为在常规组基础上应用生长激素治疗,统计分析常规组与研究组治疗前后性激素水平、正常受精率、优胚率、卵裂率以及获卵个数。结果治疗前常规组与研究组卵泡刺激素(FSH)、雌二醇(E2)以及促黄体生成素(LH)水平比较,差异均无统计学意义(P>0.05);治疗后常规组与研究组FSH及LH水平均明显降低,E2水平明显上升,研究组FSH水平低于常规组,E2水平高于常规组,差异均有统计学意义(P<0.05),两组LH水平差异无统计学意义(P>0.05);研究组正常受精率、优胚率、卵裂率以及获卵个数均高于常规组,差异有统计学意义(P<0.05)。结论卵泡期预处理使用生长激素能够更好地对高龄DOR患者性激素水平进行调节,有效提高优胚率、正常受精率、卵裂率以及获卵个数,改善患者妊娠结局,值得推广。

Objective To investigate the effect of follicular phase pretreatment with growth hormone for advanced diminished ovarian reserve(DOR)patients following the controlled ovarian hyperstimulation.Methods A total of 48 DOR patients admitted to the hospital from January 2019 to October 2020 were selected and randomly divided into routine group and study group,24 cases in each group.The routine group took the controlled ovarian hyperstimulation;on the basis of the former,the study group took the growth hormone treatment.The gonadal hormone levels,normal fertilization rate,excellent embryo rate,cleavage rate and retrieved oocyte counts were statistically analyzed.Results Before treatment,the follicle stimulating hormone(FSH),estradiol(E2)and luteinizing hormone(LH)levels between routine group and study group showed no statistically significant difference(P>0.05).After treatment,the FSH and LH levels in two groups were reduced while the E2 level was increased,the FSH level in the study group was lower than that in the routine group,the E2 level was higher than that in the routine group(P<0.05),the LH levels between routine group and study group showed no statistically significant difference(P>0.05).The normal fertilization rate,excellent embryo rate,cleavage rate and retrieved oocyte counts in the study group were significantly higher than those in the routine group(P<0.05).Conclusion The follicular phase pretreatment with growth hormone could adjust the gonadal hormone levels of advanced DOR patients,increase the normal fertilization rate,excellent embryo rate,cleavage rate and retrieved oocyte counts,and improve the pregnancy outcomes of advanced DOR patients.